This study is to evaluate the association of 9 single nucleotide polymorphisms (SNPs) with Graves' disease (GD) in different homogenous samples of the Chinese Han population. A total of 2,865 unrelated individuals were enrolled from Linyi City, Shandong Province, China, including 1,139 patients of GD and 1,726 controls. All 9 SNPs showed significant associations with GD (P < 1.3×10(-4), Bonferr...

BACKGROUND Graves' disease (GD), a highly rampant autoimmune disorder of the thyroid gland, is responsible for 60-80% of the clinical cases of hyperthyroidism. Over the past decades, genetic association studies have identified several GD susceptibility loci in CTLA-4, TSHR and major histocompatibility complex regions. The information on the association between the human leukocyte antigens (HLA)...

based on the crystal and magnetic structural properties of some gd intermetallic compounds, it is shown that with increasing conduction electron concentration, gd experiences electronic and magnetic instability, and that these behaviors point to the appearance of kondo lattice. we suggest that the conduction electrons have gained local character. it is shown that kondo effect should be observed...

To investigate the effect of Gd doping on photocatalytic activity of BiFeO3 (BFO), Gd-doped BFO nanoparticles containing different Gd doping contents (Bi(1-x)GdxFeO3, x = 0.00, 0.01, 0.03, 0.05) were synthesized using a facile sol-gel route. The obtained products were characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectra,...

– Carrier dynamics in amorphous a-Si1−xREx (RE = Gd, Y) films has been studied in the doping regime close to the metal-insulator transition by means of infrared spectroscopy. Optical constants throughout the entire intra-gap region ( ω < 1 eV) have been found to be anomalously sensitive to changes of temperature and/or magnetic field. The observed behavior is consistent with the model of hoppin...

OBJECTIVE To compare the presentation and clinical course of Graves' disease (GD) in two pediatric populations consisting of 28 patients with Down's syndrome (DS) and 109 controls without DS respectively. DESIGN AND METHODS The evolution over time of GD was determined in both groups according to the clinical changes and the variations in TSH, free thyroxine, and TSH receptor autoantibodies se...

In the UK, starch contributes up to 25 % of energy intake in adults (). The present study investigated the acute response to a starchy meal on whole-body glucose metabolism and assessed insulin sensitivity in men compared with women. Low insulin sensitivity has been postulated to pre-dispose individuals to a cluster of associated abnormalities known to increase the risk of CHD. Metabolic respon...

Cyclopamine, a steroidal alkaloid from Veratrum californicum, is teratogenic causing a range of birth defects including cyclopia (synophthalmia) as well as other craniofacial and structural malformations. Previous studies have indicated that fetuses with cyclopia are smaller, under developed, and appear premature compared to gestational matched normal fetuses. Preliminary observations suggest t...

In the objective of optimizing water exchange rate on stable, nine-coordinate, monohydrated Gd(III) poly(amino carboxylate) complexes, we have prepared monopropionate derivatives of DOTA4- (DO3A-Nprop4-) and DTPA5- (DTTA-Nprop5-). A novel ligand, EPTPA-BAA(3-), the bisamylamide derivative of ethylenepropylenetriamine-pentaacetate (EPTPA5-) was also synthesized. A variable temperature 17O NMR st...