BACKGROUND AND PURPOSE The GDC system is a valuable therapeutic alternative to surgical treatment of intracranial aneurysms. We present our clinical experience with the GDC technique used to treat unruptured cerebral aneurysms. METHODS This is a retrospective review of 217 patients with 247 unruptured intracranial aneurysms who underwent embolization with GDCs between August 1991 and June 200...

Bruton's tyrosine kinase (BTK) plays a critical role in the development, differentiation, and proliferation of B-lineage cells, making it an attractive target for the treatment of rheumatoid arthritis. The objective of this study was to evaluate the antiarthritis effect of GDC-0834 [R-N-(3-(6-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylpheny...

Using van der Pauw method, the conductivity of disk samples La0.7Sr0.3MnO3±? (LSM) and La0.6Sr0.4Co0.2Fe0.8O3?? (LSCF) in a Ce0.9Gd0.1O2?? (GDC) matrix was accurately quasi-continuously measured over 800 °C to ?73 °C, transition points Arrhenius behavior were systematically obtained from extremum second derivatives. While LSM-containing showed reproducible trajectories, LSCF system exhibited un...

The effects of the electrochemical oxygen reduction reaction (ORR) on surface single-phase perovskite cathodes are well understood, but its potential for use in a complex system consisting different material types is unexplored. Herein, we report how BaCO3 nanoparticles-modified La0.6Sr0.4Co0.2Fe0.8O3-δ-Gd0.2Ce0.8O2-δ (LSCF–GDC)-composite improved kinetics high-performing ceramic fuel cells. Bo...

Electrolyte powders with low sintering temperature and high-ionic conductivity can considerably facilitate the fabrication performance of solid oxide fuel cells (SOFCs). Gadolinia-doped ceria (GDC) is a promising electrolyte for developing intermediate- low-temperature (IT LT) SOFCs. However, conventional GDC usually above 1200 °C unless additives are used. In this work, nanocrystalline powder ...

Prosthetic lipoyl groups are required for the function of several essential multienzyme complexes, such as pyruvate dehydrogenase (PDH), a-ketoglutarate dehydrogenase (KGDH), and the glycine cleavage system (glycine decarboxylase [GDC]). How these proteins are lipoylated has been extensively studied in prokaryotes and yeast (Saccharomyces cerevisiae), but little is known for plants. We earlier ...

In C3 plants, serine synthesis is associated with photorespiratory glycine metabolism involving the tetrahydrofolate (THF)-dependent activities of the glycine decarboxylase complex (GDC) and serine hydroxymethyl transferase (SHMT). Alternatively, THF-dependent serine synthesis can occur via the C1-THF synthase/SHMT pathway. We used 13C nuclear magnetic resonance to examine serine biosynthesis b...