Description MMP2 is a Zn dependent endopeptidase, synthesized and secreted in zymogen form. The nascent form of the protein shows an N-terminal signal sequence ('pre' domain) that directs the protein to the endoplasmic reticulum. The pre domain is followed by a propeptide'pro' domain that maintains enzyme-latency until cleaved or disrupted, and a catalytic domain that contains the conserved zin...

Forty-one Enterococcus faecalis (E. faecalis) isolates from feces of pigs and chickens in Korea were screened for the presence of virulence factors. Gelatinase activity (85.4%, 35/41) was the more commonly observed phenotype of virulence in E. faecalis, compared with hemolytic activity (12.2%, 5/41). Thirty-one of 35 (88.6%) gelatinase-positive E. faecalis isolates harbored the gelE and fsrABC ...

Introduction: Enterococcus spp. has become recognized as a significant cause of hospital-acquired infections. Two main virulence factors namely gelatinase and hemolysin Enterococci have been proved to severe In addition, biofilm formation is causing infection by enhancing the persistence in medical indwelling devices. Therefore, study aimed evaluate presence hemolysin, gelatinase, impact on ant...

The gelatinase, urease, lipase, phospholipase and DNase activities of 11 chromoblastomycosis agents constituted by strains of Fonsecaea pedrosoi, F. compacta, Phialophora verrucosa, Cladosporium carrionii, Cladophialophora bantiana and Exophiala jeanselmei were analyzed and compared. All strains presented urease, gelatinase and lipase activity. Phospholipase activity was detected only on five o...

Cancer Immunotherapy In article number 2205044, Baorui Liu, Rutian Li, and co-workers constructed gelatinase-responsive NanoSwitch to control the activation process of CAR-T cells, leading on-site cells at tumor region in a sustainable way. This platform has promising potential prevent main obstacles therapy for solid tumors including cytokine-release syndrome on-target/off-tumor toxicity.