نتایج جستجو برای: gene expression programing
تعداد نتایج: 1604996 فیلتر نتایج به سال:
Background & Aims: The use of siRNA to silence gene expression is increasingly expanding today. The aim of this study is to bioinformatically and experimentally investigate the inhibition of the HMGA2 gene and its corresponding effects on downstream genes expression rate in MDA-MB-231 cancer cell treated by shRNA and siRNA specific to HMGA2. Materials & Methods: To perform this bioinformatic a...
Introduction: Endurance training has significant effects on the renewal of heart tissue, including myosin heavy chain (MHC) proteins. On the other side, Purine-rich element-binding protein &beta (purB) decreases the &alphaMHC gene expression. The aim of this study was to determine the impact of exercise endurance training on purB gene expression in the heart of Wistar rats. Methods: Fourteen r...
Backgrounds: SIRT1 plays an important role in many physiological processes, including metabolism, neuronal protection, senecence and inflammatory, by staging histones and multiple transcription factors. However, the complex mechanisms of SIRT1 signaling in tumors are not yet fully understood, as it acts as both an oncogen and a tumor suppressor. On the other hand, it has been shown that the Lnc...
Introduction: Breast cancer remains the prominent cause of mortality in women. Several biomarkers are used to evaluation the response and targeting to therapy. Tumor suppressor candidate 1 (TUSC1) gene was newly identified as a probable tumor suppressor in human cancers. Nevertheless, the expression and potential function of TUSC1 in breast cancer stay undecided. Therefore, this study aimed the...
Background Bone marrow and adipose tissue are two main sources of mesenchymal stem cells (MSCs). Some of studies suggest that there are some differences in gene expression profile of MSCs-derived from various tissues. To investigate gene expression profile by qRT-PCR, an appropriate reference gene with stable expression level should be chosen for normalizing data. This study was designed to e...
Background and Objective: Acute lymphoblastic leukemia is a disorder caused by the proliferation of malignant immature lymphoid cells. GRAF (GTPase regulator associated with focal adhesion kinase) which acts as a tumor suppressor gene is disabled in hematologic malignancies due to genetic and epigenetic abnormalities. In this study, GRAF gene expression was inspected in patients with B-ALL. ...
Background and Aim: Acute Lymphoblastic Leukemia is the most common cancer in children and is one of the main causes of their mortality. In this study, we examined the expression of long noncoding RNA CCDC26 gene and its downstream C-Kit gene in acute lymphocytic Leukemia cell line. Materials and Methods: This is an experimental study. In this study, the acute Lymphoblastic Leukemia cell lines...
Most theoretical models of evolutionary algorithms are difficult to apply to realistic situations. In this paper, two models of evolutionary program-induction algorithms (EPAs) are proposed which overcome this limitation. We test our approach with two important classes of problems — symbolic regression and Boolean function induction — and a variety of EPAs including: different versions of genet...
Abstract One of the factors that limits replacement fish meal (FM) and oil (FO) by plant ingredients in diets for marine fish, is their lack long chain-polyunsaturated fatty acids (LC-PUFA). LC-PUFA are essential these species, which sufficient acyl desaturase 2 (Fads2) activity to synthesize them. Nutritional programing or use broodstock with a higher Fads2 could improve ability low FM FO diet...
The Roman domination problem is considered. An improvement of two existing Integer Linear Programing (ILP) formulations is proposed and a comparison between the old and new ones is given. Correctness proofs show that improved linear programing formulations are equivalent to the existing ones regardless of the variables relaxation and usage of lesser number of constraints.
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