نتایج جستجو برای: gene tb
تعداد نتایج: 1164898 فیلتر نتایج به سال:
BACKGROUND Drug resistance levels and patterns among Mycobacterium tuberculosis isolates from newly diagnosed and previously treated tuberculosis patients in Mbarara Uganda were investigated. METHODS We enrolled, consecutively, all newly diagnosed and previously treated smear-positive TB patients aged >/= 18 years. Isolates were tested for drug resistance against rifampicin (RIF) and isoniazi...
The identification of immune correlates that are predictive of disease outcome for tuberculosis remains an ongoing challenge. To address this issue, we evaluated gene expression profiles from peripheral blood mononuclear cells following ex vivo challenge with Mycobacterium tuberculosis, among participants with active TB disease (ATBD, n = 10), latent TB infection (LTBI, n = 10), and previous ac...
The effective control of tuberculosis (TB) has been thwarted by the need for prolonged, complex and potentially toxic drug regimens, by reliance on an inefficient vaccine and by the absence of biomarkers of clinical status. The promise of the genomics era for TB control is substantial, but has been hindered by the lack of a central repository that collects and integrates genomic and experimenta...
SETTING: Host genetic risk factors influence the susceptibility to tuberculosis (TB). There is ample evidence supporting the involvement of toll-like receptor 4 (TLR4) in mycobacterial infection. OBJECTIVE: To study the relationship between the TLR4 gene and TB susceptibility in Sudanese. DESIGN: A case-control study was conducted by recruiting 207 patients with pulmonary TB and 395 healthy con...
A rapid, simple, and low-cost diagnostic tool for tuberculosis (TB) detection is urgently needed in countries with a high TB burden. Here, we report a novel loop-mediated isothermal amplification (LAMP) assay targeting the hspX gene for the rapid detection of Mycobacterium tuberculosis, M. bovis, M. africanum, and M. microti. The specificity of this assay was evaluated using 4 reference str...
Rapid identification of drug-resistance in Mycobacterium tuberculosis infections is crucial for early treatment and control of transmission. The MTBDRplus assay is potentially a practical and rapid alternative to the slower phenotypic drug susceptibility testing (DST) for detection of drug resistant tuberculosis (TB). The purpose of this study was to determine the diagnostic accuracy of the MTB...
background there are few quantitative documents about the seasonal incidence of tuberculosis (tb) among immigrant populations. concerning the significant role of recognizing seasonal changes of tb in improving the tb control program, this study determines the trend and seasonal temporal changes of tb among immigrants entering iran. methods in this longitudinal study, data from the iranian tb ...
BACKGROUND Introduction of Xpert® MTB/RIF assay has revolutionalised the diagnosis of tuberculosis (TB) by simultaneously detecting the bacteria and resistance to rifampicin (rif), a surrogate marker for multi-drug resistant TB (MDR-TB) as well as one of the principal first-line anti-tuberculosis drugs. In general, rpoB mutations can be found in 96.1% of rif-resistant Mycobacterium tuberculosis...
Clinical tuberculosis (TB), whether noncavitary or cavitary, is the late stage of a chronic disease process, since Mycobacterium tuberculosis is a slowly growing organism. Our studies have shown that the profiles of antigenic proteins expressed by the in vivo bacteria that elicit antibodies differ in cavitary and noncavitary TB. To gain insight into antigenic proteins expressed during incipient...
INTRODUCTION The efficacy of tuberculosis (TB) treatment in Human Immunodeficiency Syndrome (HIV) co-infected patients may be compromised by genetic and pharmacokinetic variation in drug disposition. Rifampicin is a critical component of TB treatment. We investigated the influence of drug transporter gene polymorphisms on rifampicin concentrations in TB-HIV co-infected patients in Durban, South...
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