A current major focus in genomics is the large-scale collection of genotype data in populations in order to detect variations in the population. The variation data are sought in order to address fundamental and applied questions in genetics that concern the haplotypes in the population. Since, almost all the collected data is in the form of genotypes, but the downstream genetics questions conce...

The theory of population genetics and evolutionary computation have been evolving separately for nearly 30 years. Many results have been independently obtained in both fields and many others are unique to its respective field. We aim to bridge this gap by developing a unifying framework for evolutionary processes that allows both evolutionary algorithms and population genetics models to be cast...

In our previous work [1], it has been shown that the performance of multi-objective evolutionary algorithms can be greatly enhanced if the regularity in the distribution of Pareto-optimal solutions is used. This paper suggests a new hybrid multi-objective evolutionary algorithm by introducing a convergence based criterion to determine when the modelbased method and when the genetics-based metho...

The filamentous fungus Neurospora crassa played a central role in the development of twentieth-century genetics, biochemistry and molecular biology, and continues to serve as a model organism for eukaryotic biology. Here, we have reconstructed a genome-scale model of its metabolism. This model consists of 836 metabolic genes, 257 pathways, 6 cellular compartments, and is supported by extensive ...

background: neuroblastoma is the most common extra cranial malignant solid tumor of childhood. various molecular and cytogenetic factors have been implicated in the pathogenesis of neuroblastoma, some of which have proven useful in predicting clinical behavior. over expression of the oncogen n-myc, is an important indicator of prognosis. materials and methods: our study was performed from 2004 ...

in general, both common illnesses and rare diseases can develop in people and their relatives in families. therefore, taking family history is an effective screening tool to detect such diseases and patients should be aware of its importance in families’ health with updating information in regular visiting. for more information on identifying the genetic pattern of diseases, in this article, we...

two barley (hordeun vulgare l.) genotypes, radical and cwb, with good to moderate levels of resistance to powdery mildew were crossed with a highly susceptible cultivar (afzal) to determine the genetics of resistance. the parents, fl, f2 and f3 generations of each of the two crosses, were evaluated for powdery mildew resistance in the glasshouse and field at the college of agriculture in karaj ...