background and objectives: tuberculosis (tb) is the major public health problem in the world. each year there are 2-3 million deaths worldwide caused by tb. the increasing incidence of multi drug resistance tuberculosis (mdr-tb) worldwide highlights the urgent need to search for new anti-tuberculosis compounds. it has been reported that medicinal plant, dracocephalum kotschyi, possesses some an...

background: mycobacterium tuberculosis is the causative agent of tuberculosis (tb). bacille calmette-guerin (bcg) vaccine, is not effective in adults, therefore, many efforts have been made to produce an effective adult tb vaccine. the aim of this study was to develop a new tuberculosis dna vaccine candidate encoding a recombinant hspx-ppe44-esxv fusion antigen of m. tuberculosis. methods: a fu...

background and objectives: phospholipase of mycobacterium tuberculosis plays an important role in pathogenesis through breaking up phospholipids and production of diacylglycerol. in this study, we examined the beijing strains of mycobacterium tuberculosis isolated from iranian patients for the genes encoding this enzyme. materials and methods: dna extraction was performed using ctab (cetyltrime...

Mycobacterium tuberculosis (Mtb) is a pathogenic bacteria species in the genus Mycobacterium and the causative agent of most cases of tuberculosis. Tuberculosis (TB) is the leading cause of death in the world from a bacterial infectious disease. This antibiotic resistance strain lead to development of the new antibiotics or drug molecules which can kill or suppress the growth of Mycobacterium t...

DISSEMINATED MYCOBACTERIUM TUBERCULOSIS WITH ULCERONECROTIC CUTANEOUS DISEASE PRESENTING AS CELLULITIS Abstract Cutaneous tuberculosis is a rare manifestation of infectious tuberculosis caused by invasion of the skin by Mycobacterium tuberculosis. Tuberculous cellulitis is a rare type of cutaneous tuberculosis with cellulitis-like symptoms. Only eight cases of tuberculous cellulitis have been r...

Background & Objectives: Tuberculosis is one of the greatest health problems in Iran. The distribution of the disease is not equal in all parts of the country. The aim of this study was to evaluate the frequency of positive results for Mycobacterium tuberculosis in samples referred to an academic hospital in an 8 year period. Materials and Methods: The samples from different wards of ...

Mycobacterium tuberculosis was isolated from a central venous catheter in a non-immunosuppressed patient with systemic tuberculosis. This case report represents a very uncommon form of isolation of Mycobacterium tuberculosis. A total improvement was obtained after treatment.

A retrospective analysis of the case records of patients attending the University Hospital, Tabriz, showed that over a period of 16 months, 91 patients consulted for treatment of infertility. Genital tuberculosis was diagnosed at laparotomy and confirmed histopathologically in 21(23.08%) of these patients. Genital tuberculosis is rare in Western Europe and U.S.A. but is still an important facto...

Although AIDS patients in other countries are frequently diagnosed as having atypical mycobacterial infection, in Southern Brazil there is a clinical impression that Mycobacterium tuberculosis is the rule rather than the exception. We made a retrospective review of cultures for mycobacteria at our hospital in order to determine the frequency of atypical mycobacteria and Mycobacterium tuberculos...

Tuberculosis of the vulva is very rare. It is found in about 0.2% of the cases of genital tract tuberculosis. It usually presents as small shallow ulcers and multiple sinus tracts or rarely as elephantiasis of vulva. Except for very rare cases of primary tuberculosis in the vulva, it is usually associated with tuberculosis elsewhere in the body leading to secondary tuberculosis. Here, we report...