The effects of commercial formulations Viburnum opulus and Equisetum arvense extract on anti-cytotoxicity anti-genotoxicity were evaluated at the root tip Allium cepa L. Distilled water (negative control), dimethyl sulfoxide (DMSO), ethyl methane sulfonate (EMS, positive 5% 10% doses V. E. extracts applied for 24 48 hours. Cytotoxicity genotoxicity by calculating %mitotic index %chromosomal abe...

Abstract Background Bioanalytical tools have been shown to be useful in drinking water quality assessments. Here, we applied a panel of vitro bioassays assess the treatment efficiency two pilot-scale treatments: ozonation and granular activated carbon (GAC) filtration at plant (DWTP). The systems were studied alongside full-scale process consisting biological (BAC) filtration, UV disinfection, ...

Potentially, the toxicity of multiwalled carbon nanotubes (MWCNTs) can be reduced in a safe-by-design strategy. We investigated if genotoxicity and pulmonary inflammation MWCNTs from same batch were lowered by a) reducing length b) introducing COOH-groups into structure. Mice administered: 1) long pristine MWCNT (CNT-long) (3.9 μm); 2) short CNT (CNT-short) (1 3) modified with high ratio (CNT-C...

The genotoxicity study of ornidazole (ONZ) was carried out on human lymphocyte chromosomes, using sister chromatid exchange (SCE) and micronucleus (MN). Thirty-two patients with Entemoeba histolitica infection who received 1000 mg/day for 10 days were included in this study. SCE and MN were measured before and after therapy. A statistically significant increase was observed in the SCE (P < 0.00...

Hospital effluents are serious problems in developing countries like Brazil, and when not treated adequately, can cause mutagenic effects on live organisms. Biomonitors, like Allium cepa L., which is one of the most used plant species when monitoring effluent genotoxicity, have been used to alert the world population about environmental contamination and genotoxic chemical emissions. The Allium...

Because of the increased use of alkaloids in general medical practice in recent years, it is of interest to determine genotoxic, mutagenic and recombinogenic response to different groups of alkaloids in prokaryotic and eucaryotic organisms. Reserpine, boldine and chelerythrine did not show genotoxicity response in the SOS-Chromotest whereas skimmianine showed genotoxicity in the presence of a m...

The genotoxicity induced by mitomycin C (MMC) was found to be decreased by aspirin on alkaline single cell gel electrophoresis (SCG) assay in multiple organs of mice. Aspirin at doses of 0.5, 5 and 50 mg/kg and MMC at 2 mg/kg were administered and then liver, lung, kidney, spleen, colon and bone marrow were sampled after 3 h. Significant protective effects of aspirin against MMC-induced genotox...