نتایج جستجو برای: genotyped individuals
تعداد نتایج: 340120 فیلتر نتایج به سال:
ATP Binding Cassette B1 (ABCB1) is a transporter with a broad substrate specificity involved in the elimination of several carcinogens from the gut. Several polymorphic variants within the ABCB1 gene have been reported as modulators of ABCB1-mediated transport. We investigated the impact of ABCB1 genetic variants on colorectal cancer (CRC) risk. A hybrid tagging/functional approach was performe...
The b2-adrenergic receptor (ADRB2) is an important regulator of airway smooth muscle tone. We tested the hypothesis that three functional polymorphisms in the ADRB2 gene (Thr164Ile, Gly16Arg and Gln27Glu) are associated with reduced lung function, asthma or chronic obstructive pulmonary disease (COPD). We first genotyped 8,971 individuals from the Copenhagen City Heart Study for all three polym...
We conducted a two-stage genome-wide association study to identify common genetic variation altering risk of the metabolic syndrome and related phenotypes in Indian Asian men, who have a high prevalence of these conditions. In Stage 1, approximately 317,000 single nucleotide polymorphisms were genotyped in 2700 individuals, from which 1500 SNPs were selected to be genotyped in a further 2300 in...
1 Universidad Autonoma del Estado de Morelos, CIICAp, Av. Universidad 1001, 62209 Cuernavaca, Morelos, Mexico 2 Universidad Nacional Autonoma de Mexico, Instituto de Ciencias Fisicas, Av. Universidad s/n, 62210 Cuernavaca, Morelos, Mexico 3 Instituto de Investigaciones Electricas, Reforma 113, 62490 Cuernavaca, Morelos, Mexico 4 Corrosión y Protección (CyP), Buffon 46, 11590 Mexico City, DF, Me...
In view of the serious consequences of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency and the absence of information about its incidence in the Brazilian population, we examined the frequency of the A985G mutation in the MCAD gene. A retrospective analysis was made of data on 1722 individuals (844 females) genotyped for the A985G mutation in the MCAD gene, using genomic DNA extracted fro...
OBJECTIVE To determine the association of TRIB3 Q84R polymorphism with metabolic syndrome (MetS) and carotid atherosclerosis. RESEARCH DESIGN AND METHODS A case-control study enrolled 513 Chinese subjects in three groups: control, MetS, and obese. The functional TRIB3 Q84R polymorphism was genotyped among subjects undergoing carotid ultrasonography. The clinical and biochemical characteristic...
Individuals with genotypes that code for reduced dopaminergic brain activity often exhibit a predisposition toward aggression. However, it remains largely unknown how dopaminergic genotypes may increase aggression. Lower-functioning dopamine systems motivate individuals to seek reward from external sources such as illicit drugs and other risky experiences. Based on emerging evidence that aggres...
OBJECTIVE This study was aimed at investigating the frequency of infection by Cp. psittaci and determining its genotype in individuals at potential risk of exposure to the bacteria. METHODOLOGY The study involved 170 individuals: a risk group (n= 96) and a low-risk control group (n=74). Cp. psittaci was detected and genotyped by single-tube nested PCR and ompA gene sequencing. RESULTS Eight...
Abstract The grey wolf ( Canis lupus ) is one of the most challenging species to conserve in our modern and crowded world. Due various factors, European populations are currently growing. In Hungary, numbers have increased since 2000s. Although spontaneous recolonisation from Slovakia considered be likely mechanism by majority experts, some stakeholders claim that hand-reared individuals been r...
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