BACKGROUND A number of neurological conditions have been reported to be associated with gluten sensitivity, including ataxia, peripheral neuropathy, epilepsy, and occasionally, chorea. The pathogenic role of anti-gliadin antibodies has been questioned, and pathophysiology remains controversial. CASE REPORT I report chorea in a patient with celiac disease, which responded to a gluten-restricte...

Neogen Corp. developed the Veratox R5 Gliadin test kit for the detection of gliadin based on the monoclonal antibody R5 developed by Enrique Mendez (1). The purpose of this study was to validate the method under the requirements of the AOAC Research Institute Performance Tested Method program. There are two AOAC Official Methods for gluten detection in foods, 991.19 and 2012.01 (2), both of whi...

IgA nephropathy (IgAN) presents usually as a primary disease. However, secondary forms of IgAN have been described, most commonly associated with liver disease [1]. The presence of high levels of IgA against food antigens including gliadin and IgG and IgA antiendomysial antibodies in some patients with IgAN has raised the possibility of a pathophysiological link between IgAN and coeliac disease...

Gluten refers to a complex mixture of gliadins and glutenins. It can cause numerous foodborne disorders. In sensitive individuals gluten lead celiac disease (CD), wheat sensitivity allergy. Gliadin proteins are one the fractions. The aim this paper was examine how different conditions, mixing time (2.5, 5, 7.5, 10 min) sample with most commonly solvent 70% (v/v) ethanol isopropanol incubation (...

The dynamics of the rectal surface epithelial lymphocyte and leucocyte response to wheat, gluten, and gliadin enema challenges in control individuals and in patients with coeliac sprue in remission is shown. There is a clear increase in intraepithelial lymphocytes and polymorphonuclear (PMN) leucocytes in response to these enemas in coeliac sprue, but not in controls. The peak response was at e...

Polypeptide chain weights of a-, 8and y-gliadin fractions have been estimated by polyacrylamide gel electrophoresis in the presence of mercaptoethanol and sodium dodecyl sulphate. Values lie in the range 32 000 to 44 OOO. When available data on the amino acid analyses were adjusted and compared, significant similarities emerged. It is suggested that these gliadins contain a minimum of 4 cystine...

The gluten proteins of wheat grain are responsible for visco-elastic properties flour, but they also trigger the immune-response celiac disease. In this work, two low-gliadin RNA interference (RNAi) lines that differ promoter driving silencing (D-hordein and γ-gliadin promoters D783 D793 lines, respectively), were characterized at transcriptomic, protein fraction levels in grain. Silencing glia...

BACKGROUND Celiac disease (CD) is an immune-mediated disorder induced by the ingestion of gluten in genetically susceptible persons. The prevalence of CD in Malaysia is unknown. We aim to determine the seroprevalence of CD antibodies and also investigate the correlation between H. pylori infection and CD in the young and healthy multiracial Malaysian population. METHODS Healthy young adult vo...