background: combination therapy has generated remarkable motivation in the clinical setting since it boosts the therapeutic potential of anticancer drugs. glioblastoma multiforme (gbm) is the most common and aggressive malignant brain tumor which affects patients in all ages, and being principally resistant to treatment. methods: in this study, temozolomide as a standard chemotherapeutic drug f...

BACKGROUND Chemotherapy is the commonly accepted standard therapy for most types of brain tumor, especially in medulloblastoma, primitive neuroectodermal tumor and astrocytoma. However, no efficient therapy has been established to date for glioblastoma multiforme. The aim of the present study was to analyze the activity of bortezomib in glioblastoma cell lines in comparison with that in a pedia...