Patients with Paget's bone disease (PDB) have an increased risk of developing giant cell tumor (GCT). This study was performed to evaluate the clinical characteristics and evolution of GCT complicating PDB and to compare these clinical characteristics to those observed in two large PDB cohorts, the PDB Italian Registry and the United Kingdom's Multi-Centre Randomised Controlled Trial of Symptom...

Germ cell tumours (GCTs) are the most common malignant tumours of the testes. Metastasis to cervical lymph nodes as the initial manifestation is rare. Mixed GCTs are a diagnostic challenge to the pathologist, particularly in cytology because of their histologic diversity; more so when they occur at unexpected sites, with unknown primary. Two young adult males presented with enlarged cervical ly...

Objective: Type 2 diabetes has been dramatically increasing and becoming a major public issue in China. Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy causing severe complications both for the gravida and offspring without systematic management. Furthermore, GDM can also increase the risk of developing metabolic syndrome for the mother and offspring...

Germ cell tumors (GCT) are curable cancers, but 10-15% of patients with metastatic disease fail cisplatinbased first-line therapy. While therapeutic options have increased for various other cancers no therapeutic targets have emerged in cisplatin-refractory GCT. L1 cell adhesion molecule (L1-CAM) is commonly expressed in human malignancies and therefore a potential target, however its expressio...

Ovarian granulosa cell tumor (GCT) is a rare, low-grade malignant that accounts for 70% of the sex cord-stromal tumors. It has two histopathologic types with different clinical and biologic features: adult GCT juvenile GCT. Most women diagnosed have favorable prognosis, 5-year survival rate 97%–98%, but feature late relapse; recurrence time could be more than 20 years after diagnosis. Juvenile ...

OBJECTIVES To compare the efficacy of two screenings methods for gestational diabetes mellitus, namely the universal screening using 50g Glucose Challenge Test to that of selective screening based on risk factors. METHODOLOGY A cross-sectional study involving 366 women between 24 weeks to 28 weeks gestation who attended a community health clinic for their antenatal care between January to May...

Hyperglycaemia is necessary for the diagnosis of diabetes. For more than 35 years there has been a spirited controversy about the diagnostic criteria for Type 2 diabetes, in particular about the oral glucose tolerance test (OGTT). In a 1975 paper Marvin Siperstein referred to the OGTT as ‘a pitfall in the diagnosis of diabetes mellitus’. Now the controversy has returned in the wake of the 1997 ...

BACKGROUND Glycerol 3-phosphate cytidylyltransferase (GCT) is an enzyme central to the synthesis of teichoic acids, components of the cell wall in gram positive bacteria. Catalysis by GCT from Enterococcus faecalis and Listeria monocytogenes has been investigated and catalytic properties compared. MATERIAL/METHODS The genes encoding GCT were cloned from genomic DNA and recombinant proteins ex...