The beneficial effects of exercise on type 2 diabetics have been welldocumented, including restoration of glycemic control [1-3]. At the molecular level, an increase in the translocation of glucose transporter 4 (GLUT-4) following the activation of phosphatidylinositol 3-kinase (PI3-kinase), and protein kinases B (Akt) and C ζ/λ (PKCζ/λ) improves glycemic control [4,5]. Thus, chronic exercise p...

background: the growing number of people with diabetes mellitus and its complications shows the need to focus on ways to control diabetes mellitus through improving lifestyle, dietary patterns and physical activity. this systematic review assesses the effects of healthy dietary patterns on managing hyperglycemia, insulin resistance and diabetes mellitus type 2. methods: the main keywords used i...

Signaling and insulin secretion in β cells have been reported to demonstrate oscillatory modes, with abnormal oscillations associated with type 2 diabetes. We investigated cellular glucose influx in β cells with a self-referencing (SR) microbiosensor based on nanomaterials with enhanced performance. Dose-response analyses with glucose and metabolic inhibition studies were used to study oscillat...

Mutations in the gene of the hepatic glucose-6-phosphate transporter cause glycogen storage disease type 1b. In this disease, the altered glucose homeostasis and liver functions are accompanied by an impairment of neutrophils/monocytes. However, neither the existence of a microsomal glucose-6-phosphate transport, nor the connection between its defect and cell dysfunction has been demonstrated i...

Studies in genetically engineered mice have shown the importance of cross-talk between organs in the regulation of energy metabolism. In this issue, a careful metabolic characterization of mice with genetic deficiency of the GLUT4 glucose transporter in adipocytes and muscle is reported. These mice compensate for decreased peripheral glucose disposal by increasing hepatic glucose uptake and lip...

Although the insulin secretion deficit in hypothyroid male rats has been documented, the underling mechanisms of the effect of hypothyroidism on insulin secretion are not clear. Isolated islets of the PTU-induced hypothyroid and control rats were exposed to glibenclamide, acetylcholine, and nifedipine in the presence of glucose concentrations of 2.8 or 8.3 and 16.7 mmol/L. Glucokinase and hexok...