This study examined the role of exogenous heat shock protein 72 (Hsp72) in reversing sepsis-induced liver dysfunction. Sepsis was induced by cecal ligation and puncture. Liver function was determined on the basis of the enzymatic activities of serum glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT). Apoptosis was determined using terminal deoxynucleotidyl trans...

Korean red ginseng (KRG) is prepared by the process of steaming the roots of Panax ginseng. In this study, the feeding effects of KRG-water extract (KRGE) on ethanol-induced liver damage were elucidated by measuring serum biomarkers in rats. Serum γ-glutamyltranspeptidase (γ-GT) activity and the concentration of malondialdehyde (MDA) were significantly increased by short-term and long-term etha...

Plant extracts are the most attractive sources of newer drugs and have been shown to produce promising results for the treatment of gastric ulcers. Karanjin, a furano-flavonoid has been evaluated for anti-ulcerogenic property by employing adult male albino rats. Karanjin (>95% pure) was administered to these rats in two different concentrations, that is, 10 and 20 mg kg(-1) b.w. Ulcers were ind...

OBJECTIVE To ensure the safety and evaluate the anti oxidant activity of Terminalia paniculata (T. paniculata) ethanolic extract in Sprague Dawley rats. METHODS The solvent extracts (hexane, ethyl acetate and ethanol) of T. paniculata were subjected to phytochemical analysis and their DPPH radical scavenging activity was assayed. The oral acute toxicity was evaluated using ethanolic extract o...

During our present study, we examined the W. somnifera extract effect on epinephrine induced stress. Forty Swiss albino mice were divided into three groups as non stressed group and stressed group and extract treated group .The stressed groups were exposed to 2 weeks and 4 weeks of chronic immobilization stress with epinephrine. At the end of the 2 and 4 weeks the mice were sacrificed and blood...

The present study explores the hepatoprotective activity of various extracts of Ferula asafoetida, Momordica charantia Linn and Nardostachys jatamansi against experimental hepatotoxicity. Polyherbal suspensions were formulated using extracts showing significant activity and evaluated for both physicochemical and hepatoprotective activity in comparison with LIV-52 as standard. Petroleum ether (6...

To evaluate the anti-diabetic activity of ethanolic extract of Pseudarthria viscida whole plant on Streptozotocin Nicotinamide induced type-II diabetes in rats. A crude extract of Pseudarthria viscida whole was prepared by Soxhlet extraction and the ethanolic extract was dried. At a dose of 100 mg/kg, 200mg/kg the extract was given for 14 days to evaluate the anti-hyperglycemic and anti-hyperli...

In the present study, the hepatoprotective activity of ethanolic extracts of Cassia sophera Linn. leaves was evaluated against carbon-tetrachloride- (CCl(4)-) induced hepatic damage in rats. The extracts at doses of 200 and 400 mg/kg were administered orally once daily. The hepatoprotection was assessed in terms of reduction in histological damage, changes in serum enzymes, serum glutamate oxal...

AIM To investigate the similarities and dissimilarities in patients with hepatitis B and hepatitis C, clinically and metabolically. METHODS Fifty patients with hepatitis B virus and hepatitis C virus infection were included in this study, along with fifty healthy controls for comparison purposes. Intravenous blood (10 mL) samples from patients and healthy subjects were collected and made to c...

Pet Ether, Chloroform, and Methanol extracts of roots of Blue and White flowered varieties of Clitoria ternatea (CT) were studied for their hepatoprotective potential against carbon tetrachloride (CCl4) induced hepatotoxicity in rats. The hepatoprotective activity was assessed using various biochemical parameters like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate tr...