resistance of the weanling rat to acetaminophen (ap ap)-induced hepatotoxicity is manifested with regard to a surge in apap-glutathione (osh) conjugate formation in the liver [allameh et al. mech aging dev 95(1997)71]. the present study was conducted to assess the role of this detoxification pathway in apapinduced lipid per6xidationin the liver. lipid peroxidation measured as thiobarbituric aci...

the aim of this study was to determine the effect of low levels of glutathione on post-thawed buck sperm quality. in this experiment, different concentrations of glutathione [0 (lg-0), 0.5 (lg-0.5), 1 (lg-1), 1.5 (lg-1.5), and 2 (lg-2) mm] were added in a soybean lecithin-based extender. a total of 16 ejaculates from four bucks were collected and pooled. each pooled sample was divided into five...

The livers of Geophagus brasiliensis collected from both a non-polluted site and a polluted site were analyzed for different antioxidant defenses, O2 consumption, thiobarbituric acid-reactive substance (TBARS) levels, and histological damage. Compared to controls (116.6 +/- 26.1 nmol g-1), TBARS levels were enhanced at the polluted site (284.2 +/- 25.6 nmol g-1), as also was oxygen consumption ...

Polyphenols in food plants are a versatile group of phytochemicals with many potentially beneficial activities in terms of disease prevention. In vitro cell culture experiments have shown that polyphenols possess antioxidant properties, and it is thought that these activities account for disease-preventing effects of diets high in polyphenols. However, polyphenols may be regarded as xenobiotics...

Diamide is reduced by mitochondria utilizing endogenous substrates with Vmax. 20nmol/min per mg of protein and Km 75micrometer. The reaction is inhibited by: (a) thiol-blocking reagents (N-ethylmaleimide, p-hydroxymercuribenzoate, mersalyl and 2,6-dichlorophenol-indophenol);(b) respiratory inhibitors (arsenicals, malonate and antimycin, but not cyanide or oligomycin; inhibition by antimycin is ...

this study evaluated the effect of the intermittent light program on serum and brain melatonin concentrations, antioxidant enzyme activities, and homocysteine concentration in broiler chickens. a total of 60 one-day-old broiler chickens (cobb 500) were distributed in three light-proof controlled rooms (20 chicks per room). all birds were reared in continuous light until 3 days of age. then, chi...

In previous communications (1, 2) evidence has been presented to show that vitamin Blz deficiency causes derangement in carbohydrate and lipide metabolism in the animal body, and a marked diminution of glutathione concentration in the blood. The present report describes further studies on the effect of vitamin Blz on carbohydrate and lipide metabolism, and a possible relationship between these ...

Incubation of rat hepatocytes with V. Y-bis(2-dili.rm-th> I)V-nitrn.smirea (IU AT. 10-100 MM)and 5% O caused a time-dependent loss of cell viability, whereas no cytotoxicity was observed when BCNU was incu bated with hepatocytes and 95% O2. BCNU (50-100 UM» reduced intracelluhv glutathione concentrations by 40 and 80% in hepatocytes incu bated in 95 and 5% <>., respectively. Intracellular glut...

Worldwide more than 400 plant species are now known that hyperaccumulate various trace metals (Cd, Co, Cu, Mn, Ni, and Zn), metalloids (As) and nonmetals (Se) in their shoots. Of these, almost one-quarter are Brassicaceae family members, including numerous Thlaspi species that hyperaccumulate Ni up to 3% of there shoot dry weight. We observed that concentrations of glutathione, Cys, and O-acety...