The airways are lined by several distinct epithelial cells that play unique roles in pulmonary homeostasis; however, the mechanisms controlling their differentiation in health and disease are poorly understood. The winged helix transcription factor, FOXA2, is expressed in the foregut endoderm and in subsets of respiratory epithelial cells in the fetal and adult lung. Because targeted mutagenesi...

Monoclonal antibodies against rabbit ocular mucin (ROM) and porcine stomach mucin (PSM) were developed to explore the biosynthesis and functional significance of ocular mucin. A nitrocellulose-based dot enzyme-linked immunosorbent assay (ELISA) was developed for hybridoma screening and mucin quantitation. The sensitivity was found to be at the level of 1 ng mucin per dot, which was about 1000 t...

Asian seabass (Lates calcarifer) is a food fish of increasing aquaculture importance. In order to improve our understanding on the digestive system and feeding of this species, morphological and histological features of the gut were studied. Morphologically, the Asian seabass gut is defined by a short and muscular esophagus, well-developed stomach and comparatively short intestine. Mucous secre...

1. Incipient neuroendocrine neoplasia: Dysplasia/Tis 2. True neuroendocrine tumors a. Well differentiated NETs (carcinoids, pancreatic neuroendocrine neoplasms) b. High-grade neuorendocrine carcinoma 3. Hybrid tumors a. Mixed tumors i. Mixed adenocarcinoma-neuorendocrine carcinoma ii. Mixed neuorendocrine tumor and non-neuroendocrine carcinoma iii. Duodenal gangliocytic paraganglioma b. Inciden...

Goblet cell was an indicator the health of chicken intestine that strongly influence productivity. So far, determination goblet conducted by visual used microscope. These methods required a long time and also result subjective value. The aim this study image processed for calculating number cells in assessed method applied performance. material 30 images broiler preparations with AB-PAS stainin...

BACKGROUND Neurenteric cysts are rare central nervous system lesions derived from an endodermal origin. There is no consensus concerning pathogenesis because of the paucity of occurrences. We report an immunohistochemical study of 10 cases with neurenteric cysts and postulate its pathogenesis. METHODS Ten patients underwent surgical treatment for neurenteric cysts from 1995 to 2015. We retros...

Activation of the mucosal immune system of the gastrointestinal tract in nematode infection results in altered intestinal physiology, which includes changes in intestinal motility and mucus production. These changes are considered to be under direct immunological control rather than a non-specific consequence of the inflammatory reaction to the infective agent. However, little is known about th...

Although mucins are essential for the protection of internal epithelial surfaces, molecular responses involving mucin production and secretion in response to various infectious agents in the airway have not been fully elucidated. The present study analysed airway goblet cell mucins in rats infected with the nematode Nippostrongylus brasiliensis, which migrates to the lungs shortly after infecti...