نتایج جستجو برای: gpib
تعداد نتایج: 652 فیلتر نتایج به سال:
Many snake venom proteins have been isolated that affect platelet plug formation by interacting either with platelet integrins, membrane glycoprotein Ib (GPIb), or plasma von Willebrand factor (VWF). Among them, disintegrins purified from various snake venoms are strong inhibitors of platelet aggregation. Botrocetin and bitiscetin derived from Bothrops jararaca and Bitis arietans venom, respect...
Endothelial cells secrete prothrombotic ultralarge von Willebrand factor (VWF) multimers, and the metalloprotease ADAMTS13 cleaves them into smaller, less dangerous multimers. This reaction is stimulated by tensile force applied to the VWF substrate, which may occur on cell surfaces or in the circulating blood. The cleavage of soluble VWF by ADAMTS13 was accelerated dramatically by a combinatio...
Mechanisms by which blood cells sense shear stress are poorly characterized. In platelets, glycoprotein (GP)Ib-IX receptor complex has been long suggested to be a shear sensor and receptor. Recently, a relatively unstable and mechanosensitive domain in the GPIbα subunit of GPIb-IX was identified. Here we show that binding of its ligand, von Willebrand factor, under physiological shear stress in...
The platelet collagen receptor, glycoprotein VI (GPVI), and GPIb-IX-V, which binds von Willebrand factor, initiate platelet aggregation at low or high shear stress, respectively. We recently reported that positively charged, membrane-proximal sequences within cytoplasmic domains of GPIbbeta and GPV of GPIb-IX-V bind calmodulin. We now show that GPVI also binds calmodulin as follows-(1) calmodul...
The monoclonal antibody SZ1 is of interest for two reasons: it was used to define complex formation between glycoprotein (GP) Ib and GP IX, and its epitope is likely to be identical to that recognized by most quinine- and quinidine-dependent autoantibodies that cause thrombocytopenia. To determine the location of the epitope for SZ1 within the GP Ib-IX complex (which consists of three subunits:...
were most notable in large-sized platelet subpopulations. The implication is that the bleeding tendency in these disorders is secondary to abnormal in vivo platelet-vessel wall and platelet-platelet interactions caused by decreased levels of GPIb-VIX. An interesting finding given the necessary interconnection between cytoskeletal components and membrane proteins. This suggested mechanism deserv...
At that time it was not clear that a platelet receptor was deficient, and the first clues in that direction came from studies towards the end of 1960s showing first that Bernard-Soulier platelets had less negative charge than normal platelets and this was due to decreased amounts of sialic acid (5). Studies on the major ligand for GPIb, von Willebrand factor (vWF), and its interactions with pla...
This study was designed to examine the effects of standard 22°C platelet storage and platelet cryopreservation ;pn surface glycoproteins, light scattering properties and surface-bound factor V using flow cytometry. Single donor platelet units were collected in ACD (formula A) using a^Haemonetics Mobile Collection System. The units were either liquid-preserved at 22°C with rotation for up to 7 d...
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