background : cd117 is a thyrosin kinase receptor encoded by c-kit proto-oncogene. it is expressed during normal development in some tissues and also in a subset of neoplasia especially gastrointestinal stromal tumors   (gists). treatment with thyrosin kinase inhibitors (e.g., imatinib) is useful in cd117- positive gists. the goal of this study is to investigate the expression of cd117 in glial ...

A 70 year old male presented with right lower quadrant pain and anorexia for about 72 hours prior to hospital admission. He underwent laparotomy with impression of acute appendicitis. The operative finding was an inflamed tumoral appendix without appendicular base involvement, and appendectomy was done. The patient had an uneventful post-op course. Due to the pathology report of prostatic ...

The purpose of this study was to examine the relationship between the zinc nutritional status and the factors associated with serum zinc concentration in the elderly patients in two nursing facilities: body mass index (BMI), the level of care, the grade of bedriddenness, and the grade of cognitive function. The estimations of the hematological constituents, physical index, and dietary survey we...

OBJECTIVE To evaluate the clinical efficacy of sorafenib as preoperative neoadjuvant therapy in patients with high risk renal cell carcinoma (RCC). MATERIALS AND METHODS Clinical data of 18 patients with high risk RCC who received surgery done successfully after preoperative neoadjuvant therapy with sorafenib in Peking Union Medical College Hospital (PUMCH) from April 2007 to October 2013 hav...

background and objective: gliomas are the most common primary brain tumors. despite therapeutic advances, the majority of gliomas do not respond to either chemo or radiotherapy. cd117, the gene product of c-kit has been expressed in cells of glial tumors. because gastrointestinal stromal tumors (gists) that express cd117 respond dramatically to treatment with tyrosine kinase inhibitors, identif...

1. Surgery is commonly the initial therapeutic approach. The surgical procedures are: stereotactic biopsy, open biopsy, partial resection, and complete gross resection. 2. The largest possible surgical removal is recommended; while preserving neurological function. This is to achieve: 1st an accurate histological diagnosis, avoiding underestimates of histology that sometimes can occur with ster...

Background and Objective: Male breast carcinoma (MBC) is an unusual form of neoplasia, representing 0.7 to 1 percent of all breast cancer cases. Usually, the carcinoma affects patients after the sixth decade. The aim of this study was to evaluate the status of estrogen and progesterone receptors (ER and PR) and prognostic factors (p53 and Her-2/neu) in a series of male patients with breast canc...

Mammary gland analog secretary carcinoma (MASC) of salivary gland is typically a tumor of low histologic grade and behaves as a low-grade malignancy with relatively benign course. This tumor shares histologic features, immunohistochemical profile, and a highly specific genetic translocation, ETV6-NTRK3, with secretory carcinoma of breast. Histologically, it is often mistaken as acinic cell carc...

BACKGROUND: Despite standard therapy, high grade gliomas (HGGs) have a very poor prognosis. There are numerous phase I and phase II trials investigating novel agents and multimodal approaches that seek to improve upon survival in these patients. The purpose of this study was to evaluate the therapeutic efficacy of topoisomerase inhibitors in the treatment of HGGs. METHODS: We compared the effic...