background urinary tract infection (uti) is one of the most common bacterial diseasesworldwidethat can be presented asymptomatic or symptomatic, characterized by a wide range of symptoms from mild irritative voiding to bacteremia, sepsis, or even death. in latter decades, widespread utilization of antibiotics has resulted in increased incidence of antibiotic resistance among urinary tract patho...

We conducted a prospective surveillance study of 80 hospitals across the United States to determine the incidence of sepsis syndrome and its associated sequelae in hospitalized patients over age 18 years who were administered antibiotics for suspected or documented gram-negative infection. A sample of 1754 hospitalized patients were followed from onset of antimicrobial therapy to discharge or d...

as pseudomonas, acinetobacter, and staphylococcus that appropriate disinfection can reduce these pathogens. the aim of this study was to evaluate the effect of different disinfectants on gram-negative bacteria isolated from the surface of accidents and burn hospital in yazd. materials and methods: in this study, 240 samples were randomly collected from different parts of accidents and burn hosp...

Multi-antibiotic drug-resistant (MDR) gram-negative bacilli are becoming a major threat to the standard care of septic patients. Empiric antimicrobial drug regimens to cover likely bacterial pathogens have to be altered in keeping with the spread of MDR pathogens in the health care setting and in the community. Reliable antibiotics for broad spectrum coverage for sepsis such as extended spectru...

Educational Objectives 1. Describe and calculate the dosage regimen of an aminoglycoside antibiotic for a patient with Gram negative sepsis. 2. Define the half-live of an aminoglycoside when given serum concentration time data. 3. Calculate the distribution volume of an aminoglycoside in a patient when given serum concentration time data. 4. Describe the physiologic variables which will change ...

Capnocytophaga canimorsus is a gram-negative rod that can be transmitted primarily by dog bites. This life-threatening organism commonly causes sepsis in patients with splenectomy or alcoholism. A 53-year-old rheumatoid arthritis male treated with methotrexate (MTX) for 5 years was admitted for a 4-day history of fever and dyspnea. He had been bitten on a finger by the family dog 4 days before ...

Blocking the effects of cytokines is a potential new therapeutic avenue for the treatment of Gram-negative sepsis. Three classes of agents are currently being evaluated: antibodies, circulating inhibitors, and receptor antagonists. Data in the current literature support the consideration of these agents as potential therapeutic agents in Gram-negative sepsis. The clinical utility of these agent...

We report a case of a 54-year-old man who developed gram-negative sepsis with multiorgan failure and generalized Shwartzman reaction after sustaining a dog bite. The causative organism was the fastidious gram-negative rod Capnocytophaga canimorsus, which is a commensal organism found in the oral flora of dogs and cats. More than 30 years after it was first described and despite technological ad...