Sister chromatid cohesion relies on cohesin, a complex comprising a tri-partite ring and a peripheral subunit Scc3, which is found as two related isoforms SA1 and SA2 in vertebrates. There is a division of labor between the vertebrate cohesin complexes; SA1-cohesin is required at telomeres and SA2-cohesin at centromeres. Depletion of SA1 has dramatic consequences for telomere function and genom...

Sister chromatid cohesion, which depends on cohesin, is essential for the faithful segregation of replicated chromosomes. Here, we report that splicing complex Prp19 is essential for cohesion in both G2 and mitosis, and consequently for the proper progression of the cell through mitosis. Inactivation of splicing factors SF3a120 and U2AF65 induces similar cohesion defects to Prp19 complex inacti...

Sister chromatid cohesion, which depends on cohesin, is essential for the faithful segregation of replicated chromosomes. Here, we report that splicing complex Prp19 is essential for cohesion in both G2 and mitosis, and consequently for the proper progression of the cell through mitosis. Inactivation of splicing factors SF3a120 and U2AF65 induces similar cohesion defects to Prp19 complex inacti...

Cohesion was first introduced as a software attribute that, when measured, could be used to predict properties of implementations that would be created from a given design. Unfortunately, cohesion, as originally defined, could not be objectively assessed, while more recently developed objective cohesion measures depend on code-level information. We show that association-based and slice-based ap...

The research is entitled Reference in Narrative Texts. Writer investigates hypothesis focused on reference usage.  as a part of cohesive devices grammatical cohesion, and narrative mode genre text. developed distribution frequency device. objectives this are to analyze describe (1) entities or piece informations appear refer the same referent; (2) indicator genre; (3) accurance links within t...

Bre1, a conserved E3 ubiquitin ligase in Saccharomyces cerevisiae, together with its interacting partner Lge1, are responsible for histone H2B monoubiquitination, which regulates transcription, DNA replication, and DNA damage response and repair, ensuring the structural integrity of the genome. Deletion of BRE1 or LGE1 also results in whole chromosome instability. We discovered a novel role for...

Article 2 of the Treaty on European Union (TEU) makes it clear that cohesion is one of the fundamental principles the EU seeks to respect. Cohesion, however, is not an easy concept to pin down, although it is linked (in Article 130A of the TEU) to disparities between regions. In practice, what constitutes cohesion is a political rather than an economic judgment; disparities tolerable today may ...

Cohesion increased for several months after disruption in moist soils. Rate at which cohesion increased was slower in airdry soil, but continued for years. Moduli of rupture of soils also increased with time. Effects of water content on the rate at which cohesion increases are compatible with an explanation of the bonding mechanism in terms of slightly soluble components diffusing to and cement...

In order to improve the quality of an application during the development process, developers use several metrics. These metrics measure the different software attributes such as cohesion, coupling and complexity. To measure the class cohesion several class cohesion metrics have been introduced till date. Cohesion is measured during the design phase to predict software quality. A high cohesive m...

The purpose of this study was to investigate Paralympic coaches' perceptions of team cohesion. Seven head coaches of summer and winter Canadian Paralympic sport teams participated in the study. Four participants coached individual sports and 3 coached team sports. Data were collected using semistructured interviews and analyzed using thematic analysis. The results addressed the coaches' percept...