Abstract A 46-year-old woman with Fitzpatrick skin type V presented sudden-onset accelerated diffuse hair loss. Her other relevant medical history included Graves disease. Trichoscopy showed black dots, broken hairs exclamation mark-like and yellow dots. She was provisionally diagnosed alopecia areata (AA). Laboratory work-up, including complete blood count, liver/renal parameters, antinuclear ...

Granulomatous disorders are frequently due to a wide variety of infections. Over the past decade advances in molecular diagnostic techniques have allowed identification of organisms involved in granulomatous disorders that previously were of unknown etiology. On the basis of currently available information, granulomatous infections can now be classified in three categories. Group 1 infections a...

We present a case of invasive pulmonary aspergillosis (IPA) in a previously healthy young woman who presented with what initially appeared to be an acute eosinophilic pneumonia. A second lung biopsy taken after treatment with steroids showed invasive Aspergillus with associated necrotizing granulomas, a pattern commonly found in chronic granulomatous disease (CGD). Both siblings, and by extrapo...

Lymphocytic or granulomatous hypophysitis is a rare entity with a difficult diagnosis. Our objective was to report a patient with non-tuberculous granulomatous hypophysitis. An HIV-negative 45-year old man with confusional state, subacute ophthalmoplegia, and clinical and laboratory findings of panhypopituitarism was seen in the emergency unit. A cranial MRI showed a sellar mass suggestive of h...

BACKGROUND Mastitis is a common benign disorder of the female breast. It is frequently associated with tenderness, swelling and nipple discharge. We are describing an extremely rare case of an idiopathic granulomatous mastitis in the male breast. Only 1 previous case was reported. CASE REPORT A 29-year-old male patient presented with a hard, painless lump in the right breast of 2 weeks durati...

Granulomatous inflammation of the uterus is rare, and sarcoidosis involving the uterus is even less common. Sarcoidosis is an idiopathic granulomatous disease that can affect any organ, but most typically involves the lungs, lymph nodes, spleen, liver, skin, and eye. Although it can be diagnosed clinically based on a constellation of symptoms, definitive diagnosis typically requires demonstrati...

Two patients with granulomatous lung lesions thought to be related to Crohn's disease (CD) are reported. Patient 1 was a 43-year-old man who was diagnosed with CD at age 11 years. He developed a fever in the 38 °C, and a chest X-ray and CT scan showed infiltrates with air bronchograms in the right upper lobe and left lingular segment. Transbronchial lung biopsy (TBLB) revealed granulomatous les...

Malakoplakie is a chronic granulomatous inflammatory disease, which usually affects the genitourinary tract and less frequently other sites such as, kidney, ureter, bladder, bone, lung, skin, gastrointestinal ovary.

Sarcoidosis is a systemic disease with multiorgan involvement which can cause renal failure through several different mechanisms. Granulomatous interstitial nephritis is an important albeit less frequent cause of clinically significant renal disease. Herein, we present the case of a 46 year old woman with a history of sarcoidosis whom we evaluated for rapidly worsening kidney function and prote...