Drosophila models of tauopathies have been developed by transgenically overexpressing the disease-associated forms of tau. In this paper we report for the first time that a recently developed Grape-Seed Polyphenolic Extract (GSPE) improves the eye phenotype of a Drosophila eye model of R406W tau. GSPE-mediated improvements in this distinct in vivo neurodegeneration model for protein misfolding/...

The seed and seed oil from sandbox, Hura crepitans were investigated to establish their composition and utility as a base material. Powdered seeds from H. crepitans were soxhlet-extracted with petroleum ether between 40-60°C to yield a golden-yellow oil. Proximate analyses and chemical characterization of the seed oil were carried out using the standard procedures of American Oil Chemist Societ...

Diets that ameliorate the adverse effects of uric acid (UA) on renal damage deserve attention. The effects of casein or soya protein combined with palm or safflower-seed oil on various serum parameters and renal histology were investigated on hyperuricaemic rats. Male Wistar rats administered with oxonic acid and UA to induce hyperuricaemia were fed with casein or soya protein plus palm- or saf...

BACKGROUNDS AND OBJECTIVE Several clinical trials have shown that grape seed extract can reduce blood pressure, but the results are often irreproducible. We therefore sought to systematically evaluate the impact of grape seed extract treatment on the changes of systolic/diastolic blood pressure (SBP/DBP) by meta-analyzing available randomized controlled trials. METHODS Trial selection and dat...

introduction: excessive physical exercise overproduces reactive oxygen species. even if elite sportsmen increase their antioxidant status by regular physical training, this improvement is not sufficient to limit free radical production during the competition period which can be detrimental to the body. this study evaluates the effect of grape seed supplementation along with aerobic exercise on ...