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We show how Adjoint Algorithmic Differentiation can be combined with the so-called Pathwise Derivative and Likelihood Ratio Method to construct efficient Monte Carlo estimators of second order price sensitivities of derivative portfolios. We demonstrate with a numerical example how the proposed technique can be straightforwardly implemented to greatly reduce the computation time of second order...
Although the author attacks the teleological view of history of science, he does not escape the temptation of describing the development of science-and medicine as the history of scientific discoveries. He pays very little interest to the broader intellectual milieu of scientific and medical activities. (0-631-17295-5). Henry More was to a large extent a peripheral figure in the history of the ...
The frequency of CCR5 and CCR2 alleles in human immunodeficiency virus (HIV)-positive and HIV-negative populations of Northern Greece was investigated. The frequency of the CCR5Delta32 allele among the HIV-negative subjects was 0.052, while it was approximately two-fold lower among the seropositives, suggesting that the heterozygous genotype confers a partial resistance to the HIV infection. No...
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