A previously developed mass-spring-damper model of the human body is improved in this paper, taking muscle activity into account. In the improved model, a nonlinear controller mimics the functionality of the Central Nervous System (CNS) in tuning the mechanical properties of the soft-tissue package. Two physiological hypotheses are used to determine the control strategies that are used by the c...

The determination of gait events such as heel strike and toe-off provide the basis for defining stance and swing phases of gait cycles. Two algorithms for determining event times for treadmill and overground walking based solely on kinematic data are presented. Kinematic data from treadmill walking trials lasting 20-45s were collected from three subject populations (healthy young, n=7; multiple...

The effects of various amounts of thyrotropin-releasing hormone (TRH) injected subcutaneously or intravenously (alone or in combination with growth hormone-releasing factor: GRF 1-44) on growth hormone (GH), thyroid-stimulating hormone (TSH), thyroxine (T4) and triiodothyronine (T3) were studied in the plasma of 2-week, 2-month and 3-month old lambs. After subcutaneous TRH administration, incre...

Background: The standing vertical jump (SVJ) and standing broad jump (SBJ) are athletic assessment and talent identification tools. Limited biomechanical comparison of the styles exists. The aim of this project was to assess the differences in kinetics and kinematics between SVJ and SBJ. Materials and Methods: Ten semi-professional soccer players (22.4±3.1 years) volunteered to participate in t...

As the most common type of DNA damage, DNA single-strand breaks (SSBs) are primarily repaired by the SSB repair mechanism. If not repaired properly or promptly, unrepaired SSBs lead to genome stability and have been implicated in cancer and neurodegenerative diseases. However, it remains unknown how unrepaired SSBs are recognized by DNA damage response (DDR) pathway, largely because of the lack...

The purposes of this study were to: 1) assess whole body center of mass (CM) motion in the frontal, sagittal, and transverse planes; 2) compare CM displacement with center of pressure (CP); and, 3) further define the stance and swing subphases of stair ascent (SA) and stair descent (SD) based on critical CM, CP, and ground reaction force (GRF) events. SA and SD were analyzed on a convenience sa...

PURPOSE The purpose of this study was to compare the kinematic and kinetic parameters of treadmill running to those of overground running. METHODS Twenty healthy young subjects ran overground at their self-selected moderate running speed. Motion capture and ground reaction force (GRF) data for three strides of each limb were recorded and the subjects' average running speed was evaluated. The ...

OBJECTIVES We review cases of pseudoaneurysm formation of the graft anastomosis sites following repair of type A acute aortic dissection by our original leak-proof technique for dissected aortic wall reinforcement with xenopericardium and gelatin-resorcinol-formalin (GRF) glue. CASES A 47-year-old male presented inferior acute myocardial infarction with bradycardia and cardiogenic shock 34 mo...

The consistency of ground reaction force (GRF) variables underlying dynamic transitions from bipedal to single-limb stance during a single-leg flexion movement was examined in 18 healthy adult subjects aged 21 to 47 years (mean = 31.1, SD = 8.6). Force platforms were used to measure the GRFs during fast and natural speeds of movement. Separate intraclass correlation coefficients (ICCs) were cal...

In this study we investigated the neurochemical identity of the arcuate cells activated following GH-releasing peptide-6 (GHRP-6) injection by comparing, on consecutive sections, the distribution c-fos messenger RNA (mRNA) with that of mRNAs for peptides synthesized in arcuate cells, including neuropeptide Y (NPY), GH-releasing factor (GRF), tyrosine hydroxylase, POMC, and somatostatin. Rats be...