Granulins (grns) or epithelins (epis) are peptides with molecular masses of approx. 6 kDa that modulate the growth of cells. The precursor for the grns/epis, which might itself be biologically active, is a secreted glycoprotein containing multiple repeats of the grn/epi motif. Grn/epi mRNA occurs widely in vivo, particularly in tissues rich in epithelial and haematopoietic cells. To understand ...

Computer-based surfacemodels are indispensable in several fields of science and engineering. For example, the design and manufacturing of vehicles, such as cars and aircrafts, would not be possible without sophisticated CAD and simulation tools predicting the behavior of the product. On the other hand, designers often do not like working on virtual models, though sophisticated tools, like immer...

BACKGROUND Patients with frontotemporal dementia due to mutation of progranulin may have a distinct phenotype. OBJECTIVE To identify distinct clinical and pathologic features of patients with frontotemporal dementia who have mutations of progranulin (GRN). DESIGN Retrospective clinical-pathologic study. SETTING Academic medical center. PATIENTS Twenty-eight patients with frontotemporal ...

Software engineering research has focused primarily on software construction, neglecting software maintenance and evolution. Observed is a shift in research from synthesis to analysis. The process of reverse engineering is introduced as an aid in program understanding. This process is concerned with the analysis of existing software systems to make them more understandable for maintenance, re-e...

Frontotemporal lobar degeneration is a fatal neurodegenerative disease that results in progressive decline in behavior, executive function and sometimes language. Disease mechanisms remain poorly understood. Recently, however, the DNA- and RNA-binding protein TDP-43 has been identified as the major protein present in the hallmark inclusion bodies of frontotemporal lobar degeneration with ubiqui...

Gene regulation is a complicated process. The interaction of many genes and their products forms an intricate biological network. Identification of this dynamic network will help us understand the biological process in a systematic way. However, the construction of such a dynamic network is very challenging for a high-dimensional system. In this article we propose to use a set of ordinary diffe...

Software engineering research has focused primarily on software construction, neglecting software maintenance and evolution. Observed is a shift in research from synthesis to analysis. The process of reverse engineering is introduced as an aid in program understanding. This process is concerned with the analysis of existing software systems to make them more understandable for maintenance, re-e...

Mathematical modelling and simulation can aid the analysis and design of gene regulatory networks (GRNs). GRN modelling approaches can be divided into two major categories, deterministic and stochastic. In this paper we present a new algorithm for GRN modelling called hybrid discrete algorithm (HDA). It introduces stochastic effects into an underlying deterministic approach and is based on impl...