We present Chandra observations of black hole X-ray novae V404 Cyg, A0620–00, GRO J1655–40 and XTE J1550–564 in quiescence. Their quiescent spectra can be well fitted by a power-law model with number slope α∼ 2. While a coronal (Raymond-Smith) model is also a statistically acceptable representation of the spectra, the best fit temperatures of these models is ∼ 5 times higher than that seen in a...

Components of the Par-complex, atypical PKC and Par3, have been found to be downregulated upon activation of NF-κB in intestinal epithelial cells. To determine their possible role in pro-inflammatory responses we transduced Caco-2 human colon carcinoma cells with constitutively active (ca) PKCι or anti-Par3 shRNA-expressing lentiviral particles. Contrary to previous reports in other cell types,...

Background Tumor Necrosis Factor-α(TNF- α) and Interleukin(IL-1) are well-known in the induction of senescence chondrocytes play an important role pathogenesis Osteoarthritis (OA). However, targeting these pathways has not yielded promising results. The chemokines IL-8(CXCL8) Gro-α(CXCL1), as well CXCR1/2 pathways, known to mediate inflammation apoptosis. precise OA is unknown. We hypothesize t...

We present observational evidence for “propeller” effects in two X-ray pulsars, GX 114 and GRO J1744228. Both sources were monitored regularly by the Rossi X-ray Timing Explorer (RXTE) throughout a decay period in the X-ray brightness. Quite remarkably, strong X-ray pulsation became unmeasurable when total X-ray flux had dropped below a certain threshold. Such a phenomenon is a clear indication...

During development, neuronal identity is determined by a combination of numerous transcription factors. However, the mechanisms of synergistic action of these factors in transcriptional regulation and subsequent cell fate specification are largely unknown. In this study, we identified a novel gene, Corl1, encoding a nuclear protein with homology to the Ski oncoprotein. Corl1 was highly selectiv...

Enhancer of split (E(spl)), one of the neurogenic loci of Drosophila, is uncovered by the deletion Df(3R)E(spl)(R-B251) with breakpoints at 96F8 and 96F13. We describe here the results of a genetic analysis of this chromosomal interval. Thirty-one mutations in genes of this region were recovered during various programs of mutagenesis. In addition, we included the spontaneous mutations E(spl)(D)...

The transcriptional repressor Hes1, a basic helix-loop-helix family protein, periodically changes its expression in the presomitic mesoderm. Its periodic pattern of expression is retained in a number of cultured murine cell lines. In this paper, we introduce an extended mathematical model for Hes1 oscillatory expression that includes regulation of Hes1 transcription by Drosophila Groucho (Gro) ...

The genome-wide identification of microRNA transcription start sites (miRNA TSSs) is essential for understanding how miRNAs are regulated in development and disease. In this study, we developed mirSTP (mirna transcription Start sites Tracking Program), a probabilistic model for identifying active miRNA TSSs from nascent transcriptomes generated by global run-on sequencing (GRO-seq) and precisio...