The gastrointestinal tract is a complex and dynamic network where an intricate and mutualistic symbiosis modulates the relationship between the host and the microbiota in order to establish and ensure gut homeostasis. Commensal Clostridia consist of gram-positive, rod-shaped bacteria in the phylum Firmicutes and make up a substantial part of the total bacteria in the gut microbiota. They start ...

Gut microbiota have recently been a topic of great interest in the field of microbiology, particularly their role in normal physiology and its influence on human health in disease. A large body of research has supported the presence of a pathway of communication between the gut and the brain, modulated by gut microbiota, giving rise to the term "microbiota-gut-brain" axis. It is now thought tha...

In recent years, we have seen increasing research within neuroscience and biopsychology on the interactions between the brain, the gastrointestinal tract, the bacteria within the gastrointestinal tract, and the bidirectional relationship between these systems: the brain-gut-microbiome axis. Although research has demonstrated that the gut microbiota can impact upon cognition and a variety of str...

We consider a class of seven-dimensional N = 1 supersymmetric orbifold GUTs in which the Standard Model (SM) gauge couplings and one of the Yukawa couplings (top quark, bottom quark or tau lepton) are unified, without low energy supersymmetry, at MGUT ≃ 4× 10 GeV. With gauge-top quark Yukawa coupling unification the SM Higgs boson mass is estimated to be 135± 6 GeV, which increases to 144± 4 Ge...

The gut-brain axis is the bidirectional communication between the gut and the brain, which occurs through multiple pathways that include hormonal, neural and immune mediators. The signals along this axis can originate in the gut, the brain or both, with the objective of maintaining normal gut function and appropriate behaviour. In recent years, the study of gut microbiota has become one of the ...

Sequence analysis of the five genes (gutRMCBA) downstream from the previously described sorbitol-6-phosphate dehydrogenase-encoding Lactobacillus casei gutF gene revealed that they constitute a sorbitol (glucitol) utilization operon. The gutRM genes encode putative regulators, while the gutCBA genes encode the EIIC, EIIBC, and EIIA proteins of a phosphoenolpyruvate-dependent sorbitol phosphotra...

Gut-associated lymphoid tissues (GALTs) comprise key intestinal immune inductive sites, including the Peyer’s patches of small intestine and different types isolated follicle (ILF) found along length gut. Our understanding human GALT is limited due to a lack protocols for their isolation. Here we describe technique that, uniquely among cell isolation protocols, allows identification all GALT, a...

Background: Gut microbiota play an important role in the inflammation. This study aimed to investigate whether exogenous probiotics could improve intestinal barrier function effect via attenuating inflammation and immunomodulation clinical outcomes critically ill patients.

Introduction The relationship between oral and gut microbiota in alcohol dependence (AD) is not well understood, particularly the effects of on intestinal microbiota. current study aimed to explore association AD clarify whether could ectopically colonize into gut. Methods 16S rRNA sequence libraries were used compare microbial profiles persons with healthy controls (HC). Source Tracker NetShif...

The human disease Hermansky-Pudlak syndrome results from defective biogenesis of lysosome-related organelles (LROs) and can be caused by mutations in subunits of the BLOC-1 complex. Here we show that C. elegans glo-2 and snpn-1, despite relatively low levels of amino acid identity, encode Pallidin and Snapin BLOC-1 subunit homologues, respectively. BLOC-1 subunit interactions involving Pallidin...