Following acetylation, newly synthesized H3-H4 is directly transferred from the histone chaperone anti-silencing factor 1 (Asf1) to chromatin assembly factor 1 (CAF-1), another histone chaperone that is critical for the deposition of H3-H4 onto replicating DNA. However, it is unknown how CAF-1 binds and delivers H3-H4 to the DNA. Here, we show that CAF-1 binds recombinant H3-H4 with 10- to 20-f...

ABSTRACT Introduction Increasing rates of liver transplantation and improved outcomes have led to greater numbers transplant recipients followed up in non-transplant centres. Our aim was document long-term clinical managed this ‘hub-and-spoke’ healthcare model. Methods A retrospective analysis all adult patients who underwent between 1987 2016, with post-transplant fo...

Methylation of histone H3 at lysine 4 (H3 Lys-4) or lysine 9 (H3 Lys-9) is known to define active and silent chromosomal domains respectively from fission yeast to humans. However, in budding yeast, H3 Lys-4 methylation is also necessary for silent chromatin assembly at telomeres and ribosomal DNA. Here we demonstrate that deletion of set1, which encodes a protein containing an RNA recognition ...

Background: Because of the Coronavirus disease 2019 (COVID 19) pandemic, many primary care practices have transitioned to telehealth visits keep patients at home and decrease transmission disease. Yet, little is known about nationwide capacity for delivering services via telehealth. Methods: Using 2016 National Ambulatory Medical Survey we estimated number proportion reported ...

Recent developments in au toradiography leading to the use of tr i t iated compounds in the study of biosynthetic processes have provided a basic method for accurate intracel lular localization of such labeled substances (1). The high resolution obta ined by using such compounds is a t t r ibuted to the short pa th of the beta rays emit ted by tr i t ium, 50 per cent of which are stopped in les...

Study Objective To describe the protocol and preliminary results of SAGE Registry, which characterizes long-term (5-year) outcomes transcervical fibroid ablation (TFA) with Sonata® System when used to treat symptomatic uterine fibroids in real-world use. Design Ongoing post-market global registry. Setting Up 50 clinical sites. Patients or Participants 500 wom...

Context: The COVID pandemic has renewed attention on social isolation and loneliness among older adults, while also rapidly accelerating the use of telehealth. It is unclear how loneliness, which have previously been linked with poor health outcomes, may be associated telehealth use. Objective: To assess rates in a Medicare population explore possible determinants use, includi...

AbstractBackground Little is known about the economic consequences of living with severe multiple sclerosis (SMS). Aims To assess cost-effectiveness a home-based palliative approach (HPA) for people SMS (pwSMS). direct healthcare costs in this population. Methods PwSMS from three Italian centers received (2:1 ratio) HPA or usual care over six months. Direct w...

AbstractBackground Globally, problematic internet use (PIU) is acknowledged as a significant behavioural problem in adolescents and youth. It being researched for further clarity an independent disorder. crucial to explore predictors of PIU understand the high-risk psychosocial indicators use, particularly amid COVID-19 pandemic India. Aim The present study aimed at s...