The effect of Spirulina supplementation on reduction of copper toxicity based on food utilization, phosphatases activities and selected haematological parameters was studied in a freshwater cultivable fish C. mrigala. Metal concentration in medium, body tissues and fecal matter was also analysed. Sublethal exposure of C. mrigala fed Spirulina-free diet significantly reduced the consumption and ...

Current knowledge of the haematological and onco-haematological complications of type 1 Gaucher disease has been reviewed with the aim of identifying best clinical practice for treatment and disease management. It was concluded that: (i) Awareness of typical patterns of cytopenia can help clinicians distinguish haematological co-morbidities. (ii) Red blood cell studies and complete iron metabol...

Sodium valproate is an effective antiepileptic drug used as monotherapy or adjuvant/alternative with other antiepileptic drugs. Haematological toxicity of this drug, though rare, is now an established fact and comprises mainly of neutropenia, thrombocytopenia and aplastic anemia. Very few cases of Pure Red Cell Aplasia (PRCA) following valproate therapy were reported in last 35 years but none p...

Long-term exposure to low doses of ionizing radiation may affect cells and tissues and result in various adverse health effects. The purpose of this study was to investigate whether chromosome aberrations and haematological alterations could be used as biomarkers of possible radiation injury in workers exposed to ionizing radiation. Groups totalling 323 medical professionals handling X-ray equi...

Editor’s key points † Patients with haematological malignancy requiring intensive care unit (ICU) care are often assumed to have a poor prognosis. † Analysis of 199 patients in a specialist centre had a lower ICU mortality (33%) than earlier studies. † Failure of ≥2 organ systems and mechanical ventilation were independently associated with in-hospital mortality. † The prognosis for haematologi...

Background: Extramedullary hematopoiesis is known to occur mainly in the organs of reticuloendothelial system. It is very rare for EMH to occur in thyroid nodule without any haematological abnormality. Case: A 71 year healthy male presented with 3 month history of dysphagia to solids. Clinical examination revealed thyroid nodule measuring 1 cm in diameter in right lobe of thyroid gland. FNAC wa...

OBJECTIVE To determine the clinical and haematological factors associated with treatment and outcome of chronic myeloid leukaemia (CML) at Kenyatta National Hospital. DESIGN Retrospective survey of patients treated for chronic myeloid leukaemia. SETTING Kenyatta National hospital, Nairobi, Kenya, between April 1990 and August 2000. SUBJECTS Patients with chronic myeloid leukaemia. RESUL...

BACKGROUND Enteric fever, a common infection in the tropics and endemic to India, often manifests as an acute febrile illness. However, presentation as fever of unknown origin (FUO) is not uncommon in tropical countries. METHODS We aim to describe the clinical, laboratory and pathological features of patients hospitalized with fever of unknown origin and diagnosed as enteric fever. All cultur...

OBJECTIVE To describe clinical and serological features of a large series of patients affected by primary Sjogren's syndrome (pSS), assessing the evolution of the disease in a long-term follow-up study. METHODS Clinical and laboratory data of 250 patients with pSS attending our Unit for a mean follow-up period of 140 months were retrospectively collected and analysed. In all the cases the dia...

Haematopoietic stem cell transplantation (HSCT) is a valuable tool in the treatment of many haematological disorders. Advances in understanding HLA matching have improved prognoses. However, many recipients of well-matched HSCT develop posttransplant complications, and survival is far from absolute. The pursuit of novel genetic factors that may impact on HSCT outcome has resulted in the publica...