Background. Studies using standard neuropsychological instruments have demonstrated memory deficits in patients with PTSD. We evaluated the efficacy and safety of the N-methyl-D-aspartate antagonist memantine in veterans with PTSD and cognitive impairment. Methods. Twenty-six veterans with PTSD and cognitive impairment received 16 weeks of memantine in an open-label fashion. Cognition was asses...

Fifty consecutive leg fracture patients and an equal number of age and sex matched normal controls were evaluated by psychiatric interview and mental status examination, Sinha's anxiety scale (SAS). Hamilton depression rating scale (HDRS) and the Michigan alcoholism screening test (MAST). Detailed evaluation revealed a high prevalence of alcohol dependence/ abuse (34%) and depression (8%). Leg ...

Selective estrogen receptor modulators (SERMs) such as raloxifene have already shown beneficial effects on negative, positive and general psychopathology symptoms in postmenopausal women with schizophrenia. The purpose of the present investigation was to assess the efficacy of raloxifene as an adjuvant agent in the treatment of men with chronic schizophrenia in an 8-week double-blind and placeb...

We aimed to examine the potential relationship between season of birth (SOB) and clinical characteristics in Korean patients with unipolar non-psychotic major depressive disorder (MDD). Using data from the Clinical Research Center for Depression (CRESCEND) study in South Korea, 891 MDD patients were divided into two groups, those born in spring/summer (n=457) and those born in autumn/winter (n=...

©2018 Turkish League Against Rheumatism. All rights reserved. ABSTRACT Objectives: This study aims to evaluate cerebral blood flow using color duplex Doppler ultrasonography in patients with fibromyalgia syndrome (FMS). Patients and methods: The study included 30 female patients with FMS (mean age 42.3 years; range 22 to 59 years) and 30 female healthy controls (mean age 39.6 years; range 22 to...

Predicting differential antidepressant efficacy remains an elusive goal in major depressive disorder (MDD). The aims of this study were three-fold. Firstly, to examine if psychomotor retardation symptoms (item 8 on the 17-item Hamilton Depression Rating Scale) improve preferentially to venlafaxine (VEN) over escitalopram (ESC) treatment. Secondly, whether the 18 item CORE psychomotor signs scal...

Methods 130 patients (17 with major depressive disorder (UP), 67 with major depressive episode in bipolar disorder type II (BP II), 46 with major depressive episode in bipolar disorder type I (BP I) and 50 with mixed state (MS) according to the DSM-IV criteria) were included in the study and treated with bilateral ECT, on a twice-a-week schedule. The patients were assessed before (baseline) and...

BACKGROUND This study examined the feasibility, safety and efficacy of an 8-week Relaxation Response (RR)-based group. METHODS Twenty-two depressed Chinese American immigrants were recruited. Outcomes measures were response and remission rates, the Hamilton Rating Scale for Depression, Clinical Global Impressions Scale, Quality of Life Enjoyment and Satisfaction Questionnaire, and the Multidi...

Methods: Participants, aged ≥60 years, were experiencing suboptimal response—defined as irritability, agitation, and mood lability or diminished ability to take care of basic personal needs as a result of their illness—to their current bipolar disorder medication. All patients had open-label, flexible-dose, sublingual asenapine added to their current medication for 12 weeks. Responses were eval...