Oncolytic adenoviruses represent an innovative approach to cancer therapy. These vectors are typically evaluated in immunodeficient mice with human xenograft tumors. However, in addition to being immunodeficient, this model is limited because normal and cancerous mouse tissues are poorly permissive for human adenovirus replication. This prompted us to search for a model that more accurately ref...

1. Sex and species differences during the metabolism of [4-(14)C]progesterone by liver homogenates from rat, rabbit, guinea pig and hamster have been investigated. 2. Liver homogenate from male rat formed ;water-soluble' metabolites faster and in significantly larger amounts than did liver homogenate from female rat. About 65-70% of the added progesterone was conjugated as glucuronide by liver ...

Progressive disease in the hamster model of visceral leishmaniasis, caused by Leishmania donovani, in contrast to infection in mice, mimics the progressive disease observed in untreated humans. During progressive infection in hamsters, there was a vigorous type 1 cellular immune response, which is typically associated with control of infection, suggesting that there was ineffective IFN-gamma-me...

Experimental transmission of the Stetsonville, Wisconsin, U.S.A. source of transmissible mink encephalopathy (TME) to outbred Syrian golden hamsters resulted in two distinct syndromes, termed hyper (HY) and drowsy (DY), that diverge by the third hamster passage. The syndromes differed with respect to clinical signs, incubation period, brain titre, brain lesion profile and pathogenicity in mink....

A pancreatic acinar cell-mediated mutagenicity assay was developed as an in vitro model system to study the metabolism of N-nitrosobis(2-oxopropyl)amine (BOP) and N-nitroso(2-hydroxypropyl)(2-oxopropyl)amino (HPOP) into forms mutagenic for Chinese hamster V79 cells. Mutations at the hypoxanthine:guanine phosphoribosyltransferase locus and the Na/K ATPase locus were scored by resistance to 6-thi...

Phosphomannosyl receptor (PMR) isolated from Syrian hamster liver was purified to apparent homogeneity by affinity chromatography and one-dimensional PAGE. On one-dimensional PAGE, the receptor migrated with a Mr approximately equal to 215,000 as detected by a silver-staining reagent or by immunoblotting [utilizing antiPMR generated against purified hamster PMR (Mr 215,000) sequentially purifie...

Induction of islet neogenesis by cellophane wrapping (CW) reverses streptozotocin-induced (STZ) diabetes. Administration of Ilotropin, a protein extract isolated from CW pancreata, causes recapitulation of normal islet ontogeny and reverses STZ diabetes, reducing mortality by 50%. We investigated the hypothesis that a novel gene encoding a constituent of Ilotropin was expressed in the hamster p...

Arteriolar vasomotor responses can include a component that conducts along the vessel through gap junction channels. This study examined conducted vasomotor responses in arterioles of the hypertensive hamster. The cremaster muscle of normotensive (CHF-148) and spontaneously hypertensive (CHF-H4) hamsters was exteriorized. Micropipettes containing phenylephrine (0.1 M) or acetylcholine (ACh; 1.0...

tory effects of experimental hypercorticalism.3 The visual effects of ionizing radiation on the blood flow, small blood vessels, and endothelium of capillaries and venules in the hamster cheek pouch have been studied.4 As a basis for the correlation and interpretation of these observations with respect to changes in the usual hematologic values, we have completed a study of the blood of normal ...