Ten Macaca mulatta monkeys were operantly conditioned to perform three motor paradigms designed to evaluate single and combination finger movements. Eight of these monkeys were retested after left medullary pyramidotomy; 2 monkeys underwent left medullary pyramidotomy prior to conditioning. All animals were tested for three years after operation. Monkeys with a completely sectioned medullary py...

PURPOSE This study analyzed the characteristics of responders vs. nonresponders in people with stroke receiving a novel form of repetitive transcranial magnetic stimulation (rTMS) to improve hand function. METHODS Twelve people with stroke received five treatments of 6-Hz primed low-frequency rTMS to the contralesional primary motor area. We compared demographic factors, clinical features, an...

BACKGROUND AND PURPOSE Recovery from hemiparesis due to corticospinal tract infarction is well documented, but the mechanism of recovery is unknown. Functional MRI (fMRI) provides a means of identifying focal brain activity related to movement of a paretic hand. Although prior studies have suggested that supplementary motor regions in the ipsilesional and contralesional hemisphere play a role i...

Although basic patterns of motor activity can be produced in the absence of sensory input, many different types of afferent information continuously sculpt motor output such that the intended movement responds to the environment. One type of sensory input is that derived from the skin. There are several different types of cutaneous receptors and afferents – these have been reviewed elsewhere (M...

OBJECTIVE Most rehabilitative interventions following stroke emphasize the improvement of motor deficits but rarely address sensory function and sensorimotor control. We report here a case of cerebral infarction localized to the postcentral gyrus that presented with severe impairment of motor control due to profound proprioceptive sensory loss. We attempted to demonstrate the mechanism for the ...

Spontaneous pain, hyperalgesia as well as sensory abnormalities, autonomic, trophic, and motor disturbances are key features of Complex Regional Pain Syndrome (CRPS). This study was conceived to comprehensively characterize the interaction of these symptoms in 118 patients with chronic upper limb CRPS (duration of disease: 43±23 months). Disease-related stress, depression, and the degree of acc...

BACKGROUND Trials of constraint-induced movement therapy (CIT) to improve upper extremity function after stroke have usually not included an actively treated control group. OBJECTIVE This study compared a modified CIT intervention with a dose-matched control intervention that included restraint of the less affected hand and assessed for differences in motor and functional performance and heal...