We studied the pattern of acute-phase proteins (orosomucoid, C-reactive protein, and haptoglobin) in hepatocellular deficiency due to chronic alcohol consumption, characterized by a decrease in serum transferrin concentration. We found that their patterns could vary independently of hepatocellular deficiency, but depend on the progression of hepatic disease. The most useful protein for discrimi...

Hemoglobin (Hb) plays a critical role in human physiological function by transporting O2. Hb is safe and inert within the confinement of the red blood cell but becomes reactive and toxic upon hemolysis. Haptoglobin (Hp) is an acute-phase serum protein that scavenges Hb and the resulting Hb-Hp complex is subjected to CD163-mediated endocytosis by macrophages. The interaction between Hb and Hp is...

Background Depression, schizophrenia and panic disorder are common mental disorders in the community and hospitalized patients. These mental disorders negatively affect life quality and even expectancy of life. Haptoglobin (Hp) phenotype (Hp 1-1, 1-2, or 2-2) is associated with risk for cardiovascular diseases, but its association with psychiatric disorders, a growing concern in the modern soci...

The physiologic response to a simple injury was studied in a group of 24 adults suffering from uncomplicated fractures of the tibia and fibula. The dynamic changes of different protein and glycoprotein fractions were estimated. At Days 1, 4, 10, and 30 after the fracture, there was no significant alteration in the total protein levels, but the albumin decreased (18%) and and z2-globulinsincreas...

The present study aimed to analyze sera proteins in females with cervical intraepithelial neoplasia, grade III (CIN III) and in healthy control females, in order to identify a potential biomarker which detects lesions that have a greater probability of cervical transformation. The present study investigated five sera samples from females who were Human Papilloma Virus (HPV) 16+ and who had been...

ONE electrophoresis affords a simple, rapid technique for comparing and characterizing proteins. It is especially suitable for investigations of genetically altered proteins, and notable results have come from the use of this method in studying hemoglobins (INGRAM 1961 ) and haptoglobins ( CONNELL, DIXON and SMITHIES 1962). Drosophila melanogaster is extraordinary in terms of the extensive arra...

Background: Thrombotic microangiopathy (TMA) is a serious complication of renal transplantation (Tx) and is mostly related to the prothrombotic effect of calcineurin inhibitors (CNIs). A subset of TMA (29-38%) is localized only to the graft. Case 1: A young woman suffering from adult polycistyc kidney disease (APKD) underwent kidney transplant. After 2 months, she showed slow renal deterioratio...

Research over the past 10 years in our laboratory has led to two major findings. The first is that haptoglobin (Hp) genotype can predict the risk of developing vascular complications in individuals with diabetes mellitus (DM), and the second, more far-reaching discovery, is that vitamin E treatment can significantly reduce vascular complications in individuals with DM and the Hp 2-2 genotype. T...

Haptoglobin (Hp) and serum amyloid A (SAA) are considered as the major acute phase proteins (APPs) in goats. These APPs have been investigated in several studies during the last decade. In most studies, a colorimetric assay for Hp and a solid phase sandwich ELISA for SAA have been used for quantification. In 2015, reference intervals for APPs were determined using a new type of assay, the compe...

The liver participates in the removal from the circulation of both damaged red blood cells (RBC) and plasma hemoglobin. The specific hepatic cell types involved in these processes have been identified by fractionation of rat liver into pure isolates of parenchymal and sinusoidal cells. After iniection of 59Fe-Iabeled hemoglobin, 85#{176}/o-95#{176}/o of the radioactivity in the liver was associ...