HBO has been used as an adjuvant to chemo (CT) or radiotherapy (RT) in cancer; however, in our previous work on survival study in small animal mice model, we reported cancer enhancing effect after cessation of the HBO therapy. The present study was designed to understand the underlying molecular mechanism that may be linked to cancer enhancing phenomenon. Tumor bearing C3H mice were subjected t...

formula one legend michael schumacher hit his head severely while skiing on december 29, 2013. he was operated on for brain decompression and left in a coma fighting for life. in such severe brain injury with cerebral contusion and hemorrhage following head trauma, refractory to medical therapy and with increasing cerebral oedema and intracranial pressure, critically low cerebral perfusion can ...

Introduction Hyperbaric oxygen (HBO) has been suggested to be beneficial in inflammatory bowel syndromes, mainly in Crohn’s disease, on the assumption that enteric tissue oxygenation is impaired. Several reports have shown encouraging results on the use of HBO in patients with severe or recurrent perineal CD [1-5]. The role of HBO in the pathogenesis of CD has to be determined in order to expla...

Abstract Background MicroRNA (miRNA) plays a vital role in the intervertebral disc (IVD) degeneration. The expression level of miR-573 was downregulated whereas Bax upregulated notably human degenerative nucleus pulposus cells. In this study, we aimed to investigate (NP) cells following hyperbaric oxygen (HBO) treatment. Methods NP were separated from degenerated IVD tissues. control maintained...

Hyperglycemia is known to cause oxidative stress that leads mainly to enhanced production of mitochondrial reactive oxygen species (ROS). It has been demonstrated that hyperbaric oxygen (HBO) treatment also increases the formation of ROS. There are, however, no comprehensive evaluations of such oxidative effects in diabetes which requires HBO treatment. The purpose of this study is to investiga...

We previously demonstrated that hyperbaric oxygen (HBO) treatment inhibits diet-induced atherosclerosis in New Zealand White rabbits. In the present study we investigate the mechanisms that might be involved in the athero-protective effect of HBO treatment in a well-accepted model of atherosclerosis, the apoE knockout (KO) mouse. We examine the effects of daily HBO treatment (for 5 and 10 weeks...

BACKGROUND Current treatments for osteochondral injuries often result in suboptimal healing. We hypothesized that the combination of hyperbaric oxygen (HBO) and fibrin would be superior to either method alone in treating full-thickness osteochondral defects. METHODS Osteochondral repair was evaluated in 4 treatment groups (control, fibrin, HBO, and HBO+fibrin groups) at 2-12 weeks after surgi...

Exposure of rats to hyperoxia is associated with increased active Na+ transport in rat lungs and increased Na,K-adenosine triphosphate (ATPase) expression in alveolar epithelial cells. Hyperbaric oxygenation (HBO) has been reported to act as an accelerated model of hyperoxic cell damage. Sublethal and intermittent exposure to HBO, however, has been suggested to upregulate endogenous protective ...

OBJECTIVE Hyperbaric oxygen (HBO) is a device that is used to treat foot ulcers. The study goal was to compare the effectiveness of HBO with other conventional therapies administered in a wound care network for the treatment of a diabetic foot ulcer and prevention of lower-extremity amputation. RESEARCH DESIGN AND METHODS This was a longitudinal observational cohort study. To address treatmen...

A large proportion of follicles are lost during the initial ischemia that occurs after transplantation of ovarian tissues. Thus, the effect of hyperbaric oxygen therapy (HBO) on the follicular loss of ovarian tissues after transplantation was examined in mice. Ovarian slices from ICR mice were transplanted under the kidney capsule in ovariectomized ICR. Hyperbaric oxygen with 100% oxygen was in...