Hepatocellular carcinoma (HCC) is a highly vascular tumor through the process of angiogenesis. To evaluate more non-invasive techniques for assessment of blood flow (BF) in HCC, this study examined the relationships between BF of HCC measured by computer tomography (CT) perfusion imaging and four circulating angiogenic factors in HCC patients. Interleukin 6 (IL-6), interleukin 8 (IL-8), vascula...

Introduction. Hepatitis C is the first major cause for HCC in Morocco. Antiviral treatment reduces the risk of developing HCC but few cases of HCC in HCV-treated patients were reported. We aimed to define this population's features and to identify predictive factors of developing HCC. Patients and Methods. We included all HCV carriers who developed HCC after antiviral treatment from January 200...

Pedunculated hepatocellular carcinoma (P-HCC) is rare type of HCC. The study aimed to evaluate the clinical features and outcomes of unresectable P-HCC treated with transcatheter arterial chemoembolization (TACE) and percutaneous chemotherapeutic agents lipiodol emulsion (CALE) injection. The clinical features and outcomes of 25 patients with unresectable P-HCC treated with TACE plus percutaneo...

PURPOSE Hepatocellular carcinoma (HCC) associated with chronic liver disease is known to show an obvious multistage process of tumor progression. We previously identified heat shock protein 70 as a molecular marker of early HCC during investigation of expression profiling in multistage hepatocarcinogenesis. In this report, we examined cyclase-associated protein 2 (CAP2), which is also listed as...

the imaging of hepatocellular carcinoma (hcc) is challenging and plays a crucial role in the diagnosis and staging of the disease. a variety of imaging modalities, such as ultrasound, computed tomography (ct), magnetic resonance imaging (mri) and nuclear medicine are currently used in evaluating patients with hcc. although the best option for the treatment of these cases is hepatic resection or...

this report describes a 66-year-old male who had a long history of hepatitis b virus (hbv) infection. he was found hepatocellular carcinoma (hcc) 5 months after lamivudine resistance mutation and then received a successful hepatectomy. three years later, hepatitis b envelope antigen seroconversion was achieved and nucleoside analogs were discontinued. after the withdrawn of antiviral treatment,...

1 Purpose: Metabolomics depicts metabolic changes in biological systems using a 2 multiparametric analysis technique. This study assessed the metabolomic profiles of 3 serum, obtained by proton NMR spectroscopy, from cirrhotic patients with and without 4 hepatocellular carcinoma (HCC). Experimental Design: The study included 154 5 consecutive patients with compensated biopsy-proven alcoholic ci...

BACKGROUND Hepatocellular carcinoma (HCC) is one of the most common malignant tumors occurring mainly in patients with chronic liver disease. Detection of early HCC is critically important for treatment of these patients. METHODS We employed a proteomic profiling approach to identify potential biomarker for early HCC detection. Based on Barcelona Clinic Liver Cancer (BCLC) staging classificat...

Aberrant genome-wide hypomethylation has been thought to be related to tumorigenesis. However, its mechanism and implications in hepatocellular carcinogenesis remain to be elucidated. Samples of hepatoma (hepatocellular carcinoma, HCC) and paired non-HCC liver tissues were obtained from 17 HCC patients. Normal liver tissues obtained from three individuals were used as controls. Compared with th...

BACKGROUND Biologic activities of functional mediators activate downstream transducers regulating inflammation and carcinogenesis. Correlation among mediators (IL-6, IL-27, TNF-α, and VEGF) with STAT proteins at diverse clinical-pathologic stages of hepatocellular carcinoma (HCC) remains limited. METHODS Serum mediators assayed from 147 untreated HCC cases (HCC-total group) included 70 HBV-in...