نتایج جستجو برای: hcv genotypes

تعداد نتایج: 75939  

2013
Ryozo Nagayama Fumio Tsuda Takehiro Mitsui Takeshi Tanaka Yuzo Miyakawa

Hepatitis C virus (HCV) samples in 155 sera, from patients with chronic non-A, non-B liver disease and blood donors, were grouped into four genotypes (I, II, III, and IV) by amplification of core-gene sequences by polymerase chain reaction with typespecific primers. HCV genotypes were compared with various HCV-associated antibodies detectable by the first-generation ELISA (ELISA-1) with C100-3 ...

Journal: :Journal of viral hepatitis 2005
C Payan F Roudot-Thoraval P Marcellin N Bled G Duverlie I Fouchard-Hubert P Trimoulet P Couzigou D Cointe C Chaput C Henquell A Abergel J M Pawlotsky C Hezode M Coudé A Blanchi S Alain V Loustaud-Ratti P Chevallier C Trepo V Gerolami I Portal P Halfon M Bourlière M Bogard E Plouvier C Laffont G Agius C Silvain V Brodard G Thiefin C Buffet-Janvresse G Riachi F Grattard T Bourlet F Stoll-Keller M Doffoel J Izopet K Barange M Martinot-Peignoux M Branger A Rosenberg P Sogni M L Chaix S Pol V Thibault P Opolon A Charrois L Serfaty B Fouqueray J D Grange J J Lefrère F Lunel-Fabiani

This cross-sectional study aimed to investigate, during a short period between 2000 and 2001, in a large population of patients with chronic hepatitis C, the epidemiological characteristics of hepatitis C virus (HCV) genotypes in France. Data from 26 referral centres, corresponding to 1769 patients with chronic hepatitis C were collected consecutively during a 6-month period. HCV genotyping in ...

2012
Valeria Cento Carmen Mirabelli Romina Salpini Salvatore Dimonte Anna Artese Giosuè Costa Fabio Mercurio Valentina Svicher Lucia Parrotta Ada Bertoli Marco Ciotti Daniele Di Paolo Cesare Sarrecchia Massimo Andreoni Stefano Alcaro Mario Angelico Carlo Federico Perno Francesca Ceccherini-Silberstein

BACKGROUND Because of the extreme genetic variability of hepatitis C virus (HCV), we analyzed whether specific HCV-genotypes are differently prone to develop resistance to linear and macrocyclic protease-inhibitors (PIs). METHODS The study includes 1568 NS3-protease sequences, isolated from PI-naive patients infected with HCV-genotypes 1a (N = 621), 1b (N = 474), 2 (N = 72), 3 (N = 268), 4 (N...

Journal: :hepatitis monthly 0
mahdi dehghan-manshadi immunology department, faculty of medicine, shahid sadoughi university of medical sciences, yazd, ir iran hossein hadinedoushan immunology department, faculty of medicine, shahid sadoughi university of medical sciences, yazd, ir iran; immunology department, reproductive immunology research center, shahid sadoughi university of medical sciences, yazd, ir iran; immunology department, reproductive immunology research center, shahid sadoughi university of medical sciences, yazd, ir iran. tel: +98-3536285406; +98-9133576620, fax: +98-3536238561 mohammad kazem amirbaigy gastrology department, faculty of medicine, shahid sadoughi hospital, shahid sadoughi university of medical sciences, yazd, ir iran fateme zare immunology department, faculty of medicine, shahid sadoughi university of medical sciences, yazd, ir iran gilda eslami parasitology and mycology department, shahid sadoughi university of medical sciences, yazd, ir iran seyyed ali mirghanizade-bafghi immunology department, faculty of medicine, shahid sadoughi university of medical sciences, yazd, ir iran

conclusions our findings showed that hcv infection could lead to increased expression level of tlr7 mrna in peripheral blood cells of hcv infected samples. the viral load and genotypes of hcv did not affect the mrna expression levels of tlr2 and tlr7. background hepatitis c virus (hcv) is an important human pathogen affecting an estimated 120 – 170 million individuals in the world. toll-like re...

2016
Nasheed Moqueet Curtis Cooper John Gill Mark Hull Robert W. Platt Marina B. Klein Jeff Cohen Brian Conway Pierre Côté Joseph Cox John Gill Shariq Haider Marianne Harris David Haase Mark Hull Julio Montaner Erica Moodie Neora Pick Anita Rachlis Danielle Rouleau Roger Sandre Joseph Mark Tyndall Marie-Louise Vachon Sharon Walmsley David Wong

BACKGROUND Liver fibrosis progresses faster in individuals coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV). Interferon λ3 (IFN-λ3) has both antiviral and proinflammatory properties. Genotypes at IFNL single-nucleotide proteins (SNPs; rs12979860CC and rs8099917TT) are linked to higher HCV clearance, potentially via rs8103142. We examined the relationship between IF...

Journal: :The Journal of general virology 1995
F Davidson P Simmonds J C Ferguson L M Jarvis B C Dow E A Follett C R Seed T Krusius C Lin G A Medgyesi

A method is described for identifying different genotypes of hepatitis C virus (HCV) by restriction endonuclease cleavage of sequences amplified by PCR from the 5' non-coding region. Using the enzymes HaeIII-RsaI and HinfI-MvaI, followed by cleavage with BstU1 or ScrFI, it was possible to identify and distinguish HCV genotypes 1a, 1b, 2a, 2b, 3a, 3b, 4, 5 and 6. The method was used to investiga...

Journal: :jundishapur journal of microbiology 0
fahimeh ranjbar kermani blood transfusion research center, high institute for research and education in transfusion medicine, tehran, ir iran. tel: +98-2188601501-30, fax: +98-2188601555, e-mail: [email protected] zohreh sharifi blood transfusion research center, high institute for research and education in transfusion medicine, tehran, ir iran. tel: +98-2188601501-30, fax: +98-2188601555, e-mail: [email protected]; blood transfusion research center, high institute for research and education in transfusion medicine, tehran, ir iran. tel: +98-2188601501-30, fax: +98-2188601555, e-mail: [email protected] fereshteh ferdowsian blood transfusion research center, high institute for research and education in transfusion medicine, tehran, ir iran. tel: +98-2188601501-30, fax: +98-2188601555, e-mail: [email protected] zahrah paz blood transfusion research center, high institute for research and education in transfusion medicine, tehran, ir iran. tel: +98-2188601501-30, fax: +98-2188601555, e-mail: [email protected] mahsa zamanian blood transfusion research center, high institute for research and education in transfusion medicine, tehran, ir iran. tel: +98-2188601501-30, fax: +98-2188601555, e-mail: [email protected]

background hepatitis c virus (hcv) is the main cause of infection that has the potential to cause chronic liver disease. injecting drug users (idus) have a key role in hcv transmission in iran. knowledge of the distribution of various genotypes is essential for successful future research and control strategies. objectives the aim of this study was to identify hcv genotypes among chronic infecte...

Journal: :hepatitis monthly 0
aqsa ikram atta-ur-rahman school of applied biosciences, national university of sciences and technology, islamabad, pakistan sadia anjum atta-ur-rahman school of applied biosciences, national university of sciences and technology, islamabad, pakistan; atta-ur-rahman school of applied biosciences, national university of sciences and technology, islamabad, pakistan. tel: +92-5190856152 fax+92-5190856102 muhammad tahir atta-ur-rahman school of applied biosciences, national university of sciences and technology, islamabad, pakistan

conclusions hcv gpe2 is an ideal target for hcv vaccine. prediction of epitope immunogenicity and characterization on the basis of peptide sequences will be significantly helpful for development of a heterologous vaccine against hcv variants. results many b-cell and t-cell epitopes predicted in gpe2 were found conserved among hcv 3a genotypes whereas few were conserved in other genotypes antici...

Abstract Background and Aims: IP-10 molecule is a new biomarker to predict response to treatment in chronic HCV infection. Also urine IP-10 has been suggested as a biomarker in other infections. But already, it has low data in urine as well as serum level of IP-10 for HCV infection. The aim of this study was to assess urine and serum level of IP-10 in patients with type 1 and 3a HCV infect...

Journal: :Biotechnology(Faisalabad) 2005

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