نتایج جستجو برای: hdac4
تعداد نتایج: 572 فیلتر نتایج به سال:
TRPS1, the gene mutated in human "Tricho-Rhino-Phalangeal syndrome," encodes a multi zinc-finger nuclear regulator of chondrocyte proliferation and differentiation. Here, we have identified a new function of Trps1 in controlling mitotic progression in chondrocytes. Loss of Trps1 in mice leads to an increased proportion of cells arrested in mitosis and, subsequently, to chromosome segregation de...
Fatty acids (FA) modify DNA methylation in vitro, but limited information is available on whether corresponding associations exist in vivo and reflect any short-term effect of the diet. Associations between global DNA methylation and FAs were sought in blood from lactating infants (LI; n = 49) and adult males (AMM; n = 12) equally distributed across the three conventional BMI classes. AMM provi...
Therapeutic Discovery Histone Deacetylase Cytoplasmic Trapping by a Novel Fluorescent HDAC Inhibitor
Inhibitors of histone deacetylases (HDAC) are an important emerging class of drugs for the treatment of cancers. HDAC inhibitors are currently under evaluation in clinical trials as single agents and as sensitizers in combinations with chemotherapies and radiation therapy. Although these drugs have important effects on cancer cell growth and functions, the mechanisms underlying HDAC inhibitor a...
Addiction to cocaine is commonly preceded by experiences with legal or decriminalized drugs, such as alcohol, nicotine, and marijuana. The biological mechanisms by which these gateway drugs contribute to cocaine addiction are only beginning to be understood. We report that in the rat, prior alcohol consumption results in enhanced addiction-like behavior to cocaine, including continued cocaine u...
The aggressive phenotype of RA synovial fibroblasts (RASF) is characterised by the increased expression of matrix metalloproteinase (MMP)-1 as well as the small ubiquitin like modifier (SUMO)-1 and decreased expression of SUMO-specific protease SENP1. Since we showed an increased activity of acetyltransferases in this autoimmune disease, we wanted to analyze whether this affects the expression ...
Submit Manuscript | http://medcraveonline.com Abbreviations: ACTG1: Actin Gamma 1; ARHGDIA: Rho-GDP Dissociation Inhibitor Alpha; BDMR: Brachydactyly-Mental Retardation Syndrome; CMS: Chromosomal Microarray; CNV: Copy Number Variant; FISH: Fluorescence in situ Hybridization; FSCN2: Fascin Actin-Bundling Protein 2, Retinal; TWIST2: Twist-related Protein 2; HDAC4: Histone Deacetylase 4; GPC1: Gly...
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