OBJECTIVES To quantify nailfold capillary density and dimensions in patients with idiopathic inflammatory myopathy (IIM) and compare them with those in healthy controls; to look for associations with microvascular disease in IIM; and to determine whether nailfold capillary density and dimensions change over time. METHODS Nailfold video microscopy (x300 magnification) was performed on 24 patie...

BACKGROUND NAFLD impacts patient reported outcomes (PROs). Our aim was to assess the impact of NAFLD on patients' HRQOL. METHODS National Health and Nutrition Examination Survey (NHANES) 2001-2011 data were used to identify adult patients with NAFLD [Fatty Liver Index (FLI) > 60 in absence of other liver disease and excessive alcohol >20 g/day for men, >10 g/day for women]. Patients with othe...

IMPORTANCE Alterations in glutamatergic neurotransmission have been postulated to be a key pathophysiologic mechanism in schizophrenia. OBJECTIVE To evaluate hippocampal volumetric measures and neurometabolites in unmedicated patients with schizophrenia and the correlations between these markers. Our a priori hypothesis was that glutamate levels would negatively correlate with hippocampal vol...

PURPOSE To determine whether serum levels of high mobility group box protein 1 (HMGB1) could differentiate malignant mesothelioma patients, asbestos-exposed individuals, and unexposed controls. EXPERIMENTAL DESIGN Hyperacetylated and nonacetylated HMGB1 (together referred to as total HMGB1) were blindly measured in blood collected from malignant mesothelioma patients (n = 22), individuals wit...

BACKGROUND Neuromyelitis optica (NMO), a severe demyelinating disease, represents itself with optic neuritis and longitudinally extensive transverse myelitis. Serum NMO-IgG autoantibodies (Abs), a specific finding in NMO patients, target the water channel protein aquaporin-4 (AQP4), which is expressed as a long (M-1) or a short (M-23) isoform. METHODOLOGY/PRINCIPAL FINDINGS The aim of this st...

background: this study was performed to evaluate periodontal status in patients with cardiovascular disease (cvd) and assessment of periodontal diseases prevalence in these patients. materials and methods: in this cross-sectional study, data on 100 patients were collected with mean age of 51 ± 11 years. the case group included of 50 patients with confirmed cvd who referred to ali-ibn abi talib ...

In patients with von Willebrand disease (vWD) the interest in age-related comorbidities has grown, because life expectancy of these increased. The research question this study was whether vWD show a different endothelial function compared to general population. A total 37 type 1 (n = 23), 2 10) and 3 4) vWD, 14 controls 38 coronary artery (CAD) were included study. Five markers dysfunction (MOE...

Cytokines have been important mediators of the immunity and can be involved in numerous processes in the male genital tract including acting as immunomodulatory elements within the male gonad. The aims of this study were: 1) to detect pro- and anti-inflammatory cytokine levels in the control group and subgroups of infertile men; and 2) to set up the practical recommendations concerning determin...

AIM The cardio-ankle vascular index (CAVI) is a new non-invasive marker of arterial stiffness and atherosclerosis. The purpose of this study was to compare CAVI in patients with heterozygous familial hypercholesterolemia (FH) and in healthy controls. METHODS 82 FH subjects (27 males, 65 females), aged 53.7±13.6 years without clinical symptoms of cardiovascular diseases and 359 healthy control...

Th17 response following in vitro exposure to mercury with and without n-3 long chain polyunsaturated fatty acids peripheral blood mononuclear cells from systemic lupus erythematosus patients compared healthy controls - Volume 82 Issue OCE4