purpose: hypercapnia increases minute ventilation (v’e) with little effect on heart rate (hr), whereas hypoxia may increase hr without affecting v’e. however, the effects of hypercapnia and hypoxia on both heart rate variability (hrv) and the clustering of heart beats during spontaneous breathing (respiratory sinus arrhythmia – rsa), are not clear. methods: in this study, 10 human volunteers br...

Background: Potassium, as an extracellular ion, plays an important role in the electrophysiologic function of the myocardium and any change in extracellular concentration of this ion might have a marked impression upon myocyte electrophysiologic gain. High serum potassium levels are thought to impair pulse conduction in Purkinje fibers and ventricles more than that in the Atrio...

Mitochondria play an important role in energy production for the cell. The proper function of a myocardial cell largely depends on the functional capacity of the mitochondria.  Therefore it is necessary to establish a novel and reliable method for a non-invasive assessment of mitochondrial function and metabolism in humans. Although originally designed for evaluating myocardial perfusion, 99mTc...

grape seed proanthocyanidin (gsp) bears a very powerful antioxidant effects. studies demonstrated that proanthocyanidins protect against free radicals mediated cardiovascular and renal disorders. the present study was designed to assess the effect of gsp on the heart of diabetic rats. forty rats were divided into four groups of 10 animals each: group i: control, group ii: control group were giv...

introduction:patients with cyanotic heart disease may have an acceptable quality of life. however, they are invariably prone to several complications. the aim of this study is search about hematologic abnormalities in cyanotic congenital heart disease patients. materials and methods:  in this cross sectional study every cyanotic congenital heart disease patients who was referred to the adult co...

background: diazoxide is the main therapeutic agent for congenital hyperinsulinism. the drug is generally well tolerated; however, in this report severe adverse effects including heart failure (hf) and pulmonary hypertension (ph) in an infant are reported.case report: a sixteen-day male infant with persistent hypoglycemia and with diagnosis of congenital hyperinsulinism underwent near total pan...

introduction in recent decades cardiovascular disease (cvd) is the important leading cause of death in the world. one of its most insidious forms is coronary heart disease (chd). there are a number of factors that may contribute to incidence of chd and physical and psychological side effects of it. but previous research indicates that type d personality, emotional intelligence, stress, coping s...