Hericium erinaceus, an edible and medicinal mushroom, displays various pharmacological activities in the prevention of dementia in conditions such as Parkinson's and Alzheimer's disease. The present study explored the neuroprotective effects of H. erinaceus mycelium polysaccharide-enriched aqueous extract (HE) on an l-glutamic acid (l-Glu)-induced differentiated PC12 (DPC12) cellular apoptosis ...

The Indo-Chinese species of the genus Myrmoteras are revised. We recognise one species in the subgenus Myagroteras and six species in the subgenus Mynnoteras from Vietnam, Myanmar and Thailand. Five new species are described based on the worker caste: M. concolor, M. jaitrongi, M. namphuong, M. opalinumn, and M. tonimasai, all belonging to the subgenus Myrmnoteras.

Background and aim: Basal cell carcinoma (BCC) is the most common cancer in humans. Activation of Hedgehog (Hh) signal has a key role in development of BCC. The end result of Hedgehog signal are Gli proteing. Gli 1 is a member of this family which activates DNA transcription. Previous studies showed increased expression of Gli 1 in BCC.Materials and methods: In this study 38 pathologic samples ...

Abstract. Okoli EC, Umaru IJ, Olawale O. 2023. Determination of phytochemical constituents, antibacterial and antioxidant activities ethanolic leaf extracts Pterocarpus erinaceus. Biodiversitas 24: 2272-2277. Many people in Nigeria West Africa have long used the leaves, stem bark, roots erinaceus Poir. as a medicine to treat ailments such malaria, ulcers, coughs, fevers. The antioxidant, antima...

OBJECTIVES Androgen-deprivation therapy effectively shrinks hormone-naïve prostate cancer, both in the prostate and at sites of distant metastasis. However prolonged androgen deprivation generally results in relapse and androgen-independent tumour growth, which is inevitably fatal. The molecular events that enable prostate cancer cells to proliferate in reduced androgen conditions are poorly un...

In addition to its role in embryonic development, the Hedgehog pathway has been shown to be an active participant in cancer development, progression, and metastasis. Although this pathway is activated by autocrine signaling by Hedgehog ligands, it can also initiate paracrine signaling with cells in the microenvironment. This creates a network of Hedgehog signaling that determines the malignant ...

Hedgehog signaling is known to regulate tissue morphogenesis and cell differentiation in a dose-dependent manner. Loss of Indian hedgehog (Ihh) results in reduction in pancreas size, indicating a requirement for hedgehog signaling during pancreas development. By contrast, ectopic expression of sonic hedgehog (Shh) inhibits pancreatic marker expression and results in transformation of pancreatic...

The hedgehog (Hh) signaling pathway plays a central role during embryonic development, and its aberrant activation has been implicated in the development and progression of several human cancers. Major efforts toward the identification of chemical modulators of the hedgehog pathway have yielded several antagonists of the GPCR-like smoothened receptor. In contrast, potent inhibitors of the sonic...

For homeostasis, lingual taste papilla organs require regulation of epithelial cell survival and renewal, with sustained innervation and stromal interactions. To investigate a role for Hedgehog/GLI signaling in adult taste organs we used a panel of conditional mouse models to manipulate GLI activity within epithelial cells of the fungiform and circumvallate papillae. Hedgehog signaling suppress...

Total, soluble, insoluble oxalate and mineral content of 20 edible mushrooms were measured using spectroscopic and enzymatic methods. Total oxalate content ranged from 45 (Hericium erinaceus) to 104 (Morchella conica), mg/100 g dry matter (DM), while the soluble oxalate levels ranged from 34 (Lactaius delicious) to 65 (Phellinus florida) mg/100g DM but not detected in Hericium erinaceus, Sparas...