Wilms tumor (WT) is the most common pediatric malignant primary renal tumor. Carboplatin (CRB), a platinum compound is widely used in the treatment of multiple cancers including ovarian, lung, head and neck, and wilm’s tumor. However lower uptake of CRB in cancer cells and toxicity concerns in healthy cells often limited its clinical outcome. The aim of this study was to investigate the antitum...

background: holothuroids (sea cucumbers) are members of the phylum echinodermata, which produce saponins. saponins exhibit a wide spectrum of pharmacological and biological activities. in this study, we isolated the crude saponins from the body wall of the dominant iranian species of sea cucumber, holothuria leucospilota (h. leucospilota). the purpose of this study was to confirm the presence o...

background: alpinia galanga l. belonging to the family zingiberaceae is widely grown in the state of kerala, india. they are effective antioxidant and free radical scavenger under both in vitro and in vivo condition. the efficacy of the isolated flavonoids in conferring protection from radiation induced damages to genomic dna was studied. materials and methods: the bioflavonoids, galangin and k...

As a step toward the elucidation of mechanisms in vesicle budding, a cell-free assay that measures cytosol-induced vesicle generation from liposomes was established. This assay then was used to explore the role of phosphoinositides in vesicle formation. Liposomes incubated with brain cytosol in the presence of ATP and GTP massively generated small vesicles, as assessed both quantitatively and q...

objective(s): staphylococcus aureus is an important bacterial pathogen responsible for a variety numbers of nosocomial and community acquired infections. biofilm formation is regarded as an important factor in the establishment of s. aureus infection. the contribution of the genetic background of s. aureus to biofilm formation is poorly understood. the aim of the present work was to genotype s....

biofilm of pseudomonas aeruginosa, an opportunistic pathogen, can cause serious health problems, such as chronic infections, especially in immunocompromised patients. many studies have suggested administration of new generation of antibiotics, as p. aeruginosa biofilms have developed high resistance to antimicrobial drugs. this study reports the inhibitory effect of three medicinal plant extrac...

wound infections are a common cause of staphylococcal infections. an ability of s.aureus is to adhere and form biofilm on host surfaces. biofilm is an exopolysaccharide, a slime matrix around multiple layers of cells and is mediated by expression of the icaadbc operon. the present study evaluated the biofilm forming capacity and the presence of icaad gene among s.aureus isolated from wound infe...

Since many years, membrane biofouling has been described as the Achilles heel of membrane fouling. In the present study, an ecological assay was performed using model systems with increasing complexity: a monospecies assay using Pseudomonas aeruginosa or Escherichia coli separately, a duospecies assay using both microorganisms, and a multispecies assay using activated sludge with or without spi...

Photoactivated hypericin has a potent cytotoxic effect over a wide range of cells. However, very recently hypericin has been shown to have antitumoral and antimetastatic effects in the dark. The aim of this study was to test whether hypericin in the dark affects angiogenesis. Different in vitro assays were used to study the potential effects of this compound on key steps of angiogenesis, namely...