نتایج جستجو برای: hematologic abnormalities
تعداد نتایج: 122867 فیلتر نتایج به سال:
Distorted sex ratios occur in hematologic disorders. For example, chronic lymphocytic leukemia (CLL) displays disproportionate sex ratios with a large male excess. However, the underlying genetics for these disparities are poorly understood, and gender differences for specific cytogenetic abnormalities have not been carefully investigated. We sought to provide an initial characterization of gen...
Shwachman-Diamond syndrome (SDS) is an autosomal-recessive disorder characterized by short stature, exocrine pancreatic insufficiency, and hematologic defects. The causative SBDS gene was sequenced in 20 of 23 unrelated patients with clinical SDS. Mutations in the SBDS gene were found in 75%, being identical in 11 patients. Hematologic parameters for all 3 lineages were determined over time suc...
Of 11 children with juvenile myelomonocytic leukemia (JMML) carrying RAS mutations (8, NRAS mutations; 3, KRAS2 mutations), 5 patients had a profound elevation in either or both the WBC and spleen size at diagnosis. Three patients had no or modest hepatosplenomegaly and mild leukocytosis at presentation, but subsequently showed a marked increment in spleen size with or without hematological exa...
INTRODUCTION Nontraumatic osteonecrosis (ON) has been proven to be associated with alcohol abuse in many published reports (1). However, the pathogenesis of alcohol-induced ON remains unclear. Some reports suggested that pathologic changes in steroidand alcohol-induced ON are similar (1). Several possible factors in the pathogenesis of steroidinduced ON have been suggested based on human and an...
BACKGROUND The coexistence of t(9;22)(q34;q11.2) and inv(16)(p13q22) chromosomal abnormalities is extremely uncommon, and only a small number of such cases have been reported. Here, we characterized 7 cases of hematologic malignancy exhibiting t(9;22) and inv(16) coexistence. METHODS We reviewed the cytogenetic data for hematologic malignancies treated at the Catholic Blood and Marrow Transpl...
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