OBJECTIVES Pioglitazone (Actos) is one of the most controversial recent oral antidiabetic drugs. It was originally authorized in the European Union in 2000, and approved as an oral monotherapy for overweight second type of diabetic patients in 2002. It belongs to the thiazolidinedione group which some of its members have been withdrawn from the market due to the hepatotoxicity or cardiotoxicity...

The acute and sub-acute toxicity of safranal were studied in rat and mice within 2 and 21 days after exposure, respectively. For subacute toxicity, changes in weight as well as biochemical, hematological and pathological parameters were studied. The intraperitoneal LD50 values of safranal were 1.48 mL/kg in male mice, 1.88 mL/kg in female mice and 1.50 mL/kg in male rats. Oral LD50 values were ...

INTRODUCTION Canine visceral leishmaniasis (CVL) is a zoonotic disease with different clinical manifestations. Parasitism often occurs in bone marrow, but changes have been observed in peripheral blood and serum biochemical parameters. The aim of this study was to evaluate the hematological and biochemical parameters in dogs naturally infected by Leishmania chagasi. METHODS Eighty-five adult ...

Spondias tuberosa Arruda, popularly named as umbu, is native from savanna-like vegetation and widely used for medicinal purposes, however, the toxicological profile is not available yet. This study evaluated the phytochemical profile and acute toxicity and citoxicity of Ethanolic Extract of Spondias tuberosa Arruda Bark (EEStb) in hematological, biochemical and histopathological parameters. Fem...

In vertebrates living at high altitude, arterial hypoxemia may be ameliorated by reversible changes in the oxygen-carrying capacity of the blood (regulated by erythropoiesis) and/or changes in blood-oxygen affinity (regulated by allosteric effectors of hemoglobin function). These hematological traits often differ between taxa that are native to different elevational zones, but it is often unkno...

The purpose of the research is study pharmaco-toxicological properties Ornidazole- and Levamisole hydrochloride-based drug. Materials methods . drug were studied in premises Laboratory Preclinical Studies, Faculty Veterinary Medicine, Stavropol State Agrarian University. Acute chronic toxicity, irritant effect was under Guidelines for Studies Drugs (2012). Hematological studies laboratory anima...

Our view refer to clarify the seroprevalence of brucellosis infection in dairy cows Menoufiya Governorate and evaluate hematological, biochemical immunological parameters changes blood infected compared healthy ones. Blood samples 100 (3-5) years from private farm abattoir were screened for Brucella using (BAPAT) test groups, first group(25) serum serologically second group (75) negative (healt...

BACKGROUND: Comprehensive studies in blood values t have been somewhat reported in wildlife animals but this study is the first one in Iranian red sheep. OBJECTIVES: The present study was aimed to reveal alterations of some biochemical and hematological parameters in Iranian red sheep (Ovis. Orientalis gmelini) in the Zanjan province (Sorkhabad p...