BACKGROUND AND PURPOSE Functional MR (fMR) imaging with blood-oxygen-level-dependent (BOLD) contrast enhancement is increasingly used as a noninvasive tool for presurgical mapping in patients with intracranial tumors. Most physiologic studies of task-related BOLD contrast enhancement have involved healthy volunteers. Therefore, it is not known whether BOLD contrast is evoked in the same way in ...

The line-bisection task is the standard assessment of unilateral visual neglect. It supplies one effect, the crossover effect, that challenges models of neglect: in left neglect, the rightward displacement of the midpoint of the line becomes a left displacement for small lines. We review the various attempts to account for the cross-over effect, before describing a computational model of perfor...

Many birds fly non-stop for days or longer, but do they sleep in flight and if so, how? It is commonly assumed that flying birds maintain environmental awareness and aerodynamic control by sleeping with only one eye closed and one cerebral hemisphere at a time. However, sleep has never been demonstrated in flying birds. Here, using electroencephalogram recordings of great frigatebirds (Fregata ...

BACKGROUND AND PURPOSE High experimental variability in mouse embolic stroke models could mask the effects of experimental treatments. We hypothesized that imaging thrombus directly would allow this variability to be controlled. METHODS We optically labeled thrombi with a near-infrared fluorescent (NIRF) probe C15 that is covalently linked to fibrin by factor-XIIIa. Labeled thrombus was injec...

Elevated intracranial pressure (i.e. intracranial hypertension) is a potentially devastating sequela of neurologic injury, often complicating catastrophic brain injury such as deep intracerebral hematoma and hemispheric ischemic stroke. Despite initial compensatory mechanisms, elevated ICP directly leads to mechanical compression and distortion of brain tissue as well as hypoxic-ischemic injury...