Haemophagocyticy lymyphohistiocytosis in the new-born is uncommon. Incidence reported between 1 50,000 to 1,50,000 admissions. Usually it primary or familial HLH first year of life. Secondary causes are due viral, bacterial and fungal infections. A dysmorphic small for gestational age male neonate presented with sepsis neonatal cholestasis. He also had associated HLH. Exom sequencing showed a 2...

hemophagocytic lymphohistiocytosis (hlh) is an aggressive and potentially life-threatening disease and has to be considered in the differential diagnosis of many conditions. hlh comprises two different conditions that are difficult to differentiate; familial hemophagocytic lymphohistiocytosis (fhlh) or familial erythrophagocytic lymphohistiocytosis (fel), and secondary hemophagocytic syndromes ...

EDITORIAL Hemophagocytic lymphohistiocytosis as a possible cause of prolonged fever, splenomegaly, and cytopenia Linfohistiocitosis hemofagocítica como posible cause de fiebre prolongada, espelomegalia y citopenia Hyperinflammatory response may be one of the causes for a long-lasting unexplained fever in children and adults. 1 Clinical syndrome of the exaggerated inflammatory reaction is called...

BACKGROUND HIV clinical presentation in the acute stage is variable and some of its virological and immunological aspects are not completely understood. Most cases of HIV- associated reactive hemophagocytic syndrome have been reported in patients with advanced stages of HIV and to our knowledge, there are only 8 cases in the English literature presenting during acute HIV infection, most in East...

Hemophagocytic lymphohistiocytosis (HLH) or Macrophage Activation Syndrome (MAS) is a potentially life threatening disorder that presents with fever, suppressed blood cell counts, hepatosplenomegaly and multi-organ failure. HLH has been reported in association with genetic mutations, infections, autoimmune disorders, and various malignancies. However to the best of our knowledge, HLH in associa...