Hemophilia is an X-linked recessive bleeding disorder caused by deficiency of FVIII (hemophilia A) or FIX (hemophilia B). Mutations in the FVIII or FIX genes, both located on the long arm of the X chromosome, are detectable in the majority of cases of hemophilia A or B, respectively. During normal hemostasis, FVIII and FIX form an enzymatic complex; thus, deficiency of either protein leads to a...

conclusions more than 40% of the hemophilic patients under 20 years of age in the present study had no immunity against hepatitis a, and 23% of hepatitis c patients had not had a hepatitis a co-infection yet. since hepatitis a can show a fulminant course in hepatitis c patients, vaccination against hepatitis a seems necessary in hemophilic patients in the region. background hemophilic patients ...

Having a healthy life is the right of every human being. The State has to help people live and support suffering from any disease. In this article, researcher focuses on one diseases called Hemophilia. Hemophilia bleeding genetic disorder. It included in Rights People with Disability Act, 2016. highly neglected There no research legal perspective topic. This paper will understand hemophilia gap...

Improvements in hemophilia care and antiviral treatments have resulted in increases in median life expectancy for persons with congenital hemophilia A and B. Currently, 2% of hemophilia A and B patients surveyed in US comprehensive hemophilia treatment centers are 65 years of age or older and 15% are 45 years or older. Many of the complications of hemophilia, including intracranial hemorrhage, ...

Individuals with hemophilia are deficient in one of the clotting factor proteins that are vital in the formation of a clot. Classic hemophilia or hemophilia A is a deficiency of factor VIII, while Christmas Disease or Hemophilia B is a deficiency of factor IX. The deficiency of one of these proteins comes about because of a mutation on the X chromosome. Patients with both types of hemophilia ar...

Regulation of age-related changes in gene expression underlies many diseases. We previously discovered the first puberty-onset gene switch, the age-related stability element (ASE)/age-related increase element (AIE)-mediated genetic mechanism for age-related gene regulation. Here, we report that this mechanism underlies the mysterious puberty-onset amelioration of abnormal bleeding seen in hemop...

J Adv Med Educ Prof. July 2015; Vol 3 No 3 Dear Editor, A hemophilia is a chronic bleeding disease and can interfere with daily performance of children, these children require continuous training to prevent bleeding and take timely action (1). Since children nurses play an important role in the education of involved children and their Selfefficacy and also due to today’s approach which is using...

We recently described tolerance induction with factor VIII/IX, cyclophosphamide, and high-dose intravenous IgG in hemophilia A or B patients with coagulation inhibitory antibodies. Circulating noninhibitory antibodies complexed with factor IX have been demonstrated in tolerant hemophilia B patients. Similar findings are now described in six tolerant hemophilia A patients. Complexes between fact...