Studies of hepatic bile formation reported in 1958 established that it was an osmotically generated water flow. Intravenous infusion of sodium taurocholate established a high correlation between hepatic bile flow and bile acid excretion. Secretin, a hormone that stimulates bicarbonate secretion, was also found to increase hepatic bile flow. The sources of the water entering the biliary system w...

Jiaqi Ganxian Granule (JGG) is a famous traditional Chinese medicine, which has been long used in clinical practice for treating liver fibrosis. However, the mechanism underlying its anti-hepatic fibrosis is still not clear. In this study, an Ultra-Performance Liquid Chromatography-Time-Of-Flight Mass Spectrometry (UPLC-TOF-MS)-based metabolomics strategy was used to profile the metabolic chara...

Although many studies have been performed on the effects of ultraviolet (UV) radiation on the skin, only a limited number of reports have investigated these effects on non-skin tissue. This study aimed to describe the metabolite changes in the liver of hairless mice following chronic exposure to UVB radiation. We did not observe significant macroscopic changes or alterations in hepatic choleste...

BACKGROUND Tumor progression locus 2 (TPL2), a serine-threonine kinase, functions as a critical regulator of inflammatory pathways and mediates oncogenic events. The potential role of Tpl2 in nonalcoholic fatty liver disease (NAFLD) associated hepatocellular carcinoma (HCC) development remains unknown. METHODS Both wild-type and Tpl2 knockout male mice were initiated by a hepatic carcinogen (...

The effects of fibre-enriched biscuit on biomarkers associated with hepatotoxicity in diabetic rats were investigated. Diabetes was induced by single intraperitoneal injection of alloxan monohydrate. Treatment lasted for 14 days after which the rats were sacrificed by cervical dislocation. Blood serum was analyzed to determine hepatic function enzymes. The liver was also analyzed to determine h...

Publications concerning the protective effect of pectin against lead induced toxicity in rats are not available. In order to study such effect, 40 male were divided into 3 groups. The first group was contained 10 that kept as control group. second received at dose 100 mg/kg BW during experimental period (8 weeks). third 20 400mg/kg acetate daily for 4 weeks then two subgroups (3A and 3B). Subgr...

hydatid disease, caused by echinococcusgranulosus, is a common parasitic infection of the liver. disseminated intra-abdominal hydatid disease may occur with the rupture of the hydatid cyst into the peritoneal cavity, producing secondary echinococcosis. but primary hydatid cyst in the pelvis is rare. we report a case of bilateral hydatid cyst of the pelvis in a 53years old woman presented with a...

Haematological, hepatic and oxidative stress parameters in juvenile Clarias gariepinus exposed to a combined ternary mixture of naphthalene, phenanthrene benzo[a]pyrene were investigated under static-renewal bioassay conditions. The test organisms two levels treatments the mixed compounds for period 35 days. Red blood cell (RBC) count, haemoglobin (Hb) concentration haematocrit (Hct) significan...