We previously developed a method of detecting drug-resistant mutation of hepatitis B virus (tyrosine (Y)-methionine (M)-aspartic acid (D)-aspartic acid (D) (YMDD) mutation) caused by the antiviral agent lamivudine. Using this method, we also reported that YMDD mutation is present in asymptomatic carriers that had not been administered antiviral agents. Thus, we investigated the clinical charact...

abstract background: hepatitis b virus (hbv) infection in patients who lack detectable hepatitis b surface antigen (hbsag) is called occult hepatitis b infection. such infections have been frequently identified in patients with chronic hepatitis cliver disease, but their prevalence is not known. methods: 207 patients with chronic hepatitis c who were hcv -rna and antihcv positive were studied f...

results the results of this study indicated that the overall hepatitis b vaccine acceptance rate was acceptably high. among all, 53.5% correctly identified that a vaccine to prevent hepatitis b virus infection had been available, 15% had a negative opinion, and 31.5% were neutral. the rations of all three doses of vaccination were 69.3%. conclusions among the respondents, 87% were currently mar...

Post-transplant malignancy is the major cause of later death of recipients after liver transplantation. Tumor recurrence after liver transplantation for patients with hepatocellular carcinoma in the end stage of cirrhosis has been frequently encountered. However, de novo hepatocellular carcinoma originating from the liver allograft has only rarely been reported. Here we reported a case of de no...

Infection with hepatitis B virus leads to a wide spectrum of liver injury, including self-limited acute hepatitis, fulminant hepatitis, and chronic hepatitis with progression to cirrhosis or acute exacerbation to liver failure, as well as an asymptomatic chronic carrier state. Several studies have suggested that the hepatitis B core antigen could be an immunological target of cytotoxic T lympho...

Hepatitis B virus (HBV) is an enveloped virus with a small (3.2-kb) partially double-stranded DNA genome that causes acute and chronic infections. The impact of these infections on public health worldwide is enormous, with an estimated prevalence of 2 billion acute infections and 360 million chronic infections globally. This review focuses on chronic hepatitis B and the molecular assays used in...

today, chronic viral hepatitis is considered as a public health problem in the world. totally, 5% of the world population, especially in asia and africa suffer from this problem. the prevalence of acute hepatitis in america is 0.1-0.2 percent, 50% of those with hepatitis c (hcv) and 5-10% of them with hepatitis b (hcv) develop chronic hepatitis. determining hbv and hcv genotypes is important to...

Background: Hemophilia A and B are the most frequent congenital coagulation disorders. This study was conducted to determine the prevalence of hepatitis B, C and human immunodeficiency viruses among hemophilic patients in Hamadan, Iran. Patients and Methods: In this study, patients with hemophilia A and B treated in Hamedan Hemophilia Center, Hamedan, Iran, were screened for hepatitis B, C and...

PURPOSE Lamivudine is known to be very effective in suppressing hepatitis B virus replication and virus induced necroinflammation. The aim of this study was to evaluate lamivudine therapy efficacy, predictive factors, breakthrough, prevalence of YMDD mutation, and relapse rate in Korean children with chronic hepatitis B. MATERIALS AND METHODS Between August 1999 and February 2005, 60 children...

BACKGROUND Since the introduction of Highly Active Anti-Retroviral Therapy and the dramatic improvement in the prognosis of individuals with Human Immunodeficiency Virus, liver disease due to chronic viral hepatitis has become as important cause of morbidity and mortality in co-infected individuals. The objective of the study was to determine the Sero-prevalence of Hepatitis B Virus, Hepatitis ...