background: full blood count has been shown to predict disease severity and mortality risk in cancer patients. this study aimed to highlight the degree of derangements of full blood count parameters and provide mean values in pre-chemotherapy breast cancer patients compared with apparently normal control subjects.methods: this was an unmatched case-control study among breast cancer patients att...

conclusions: saffron, as an antioxidant, is positively effective on sperm parameters in rats exposed with cadmium. objectives: the aim of this study was to determine the effects of saffron on the results of semen parameters (sperm concentration, motility and viability in cauda of epididymis) in rats exposed to cadmium. materials and methods: thirty wistar male rats were divided into four groups...

to assess the effects of pre-analytical handling (storage time and temperature) on selected hematological parameters, whole blood samples were collected in edta coated tubes from each of 30 clinically normal male adult beagle dogs. each sample was separated in 2 aliquots, of which one was stored in ambient temperature (25 ˚c) and the other one was refrigerated (2 to 4 ˚c). complete blood counts...

background: myocardial infarction is the major cause of morbidity and mortality in industrialized countries. platelet count and the mean platelet volume (mpv), a simple and reliable indicator of platelet size which correlates with platelet activation, might associate with troponin in acute chest pain. methods: we analyzed mpv of 851 patients who were admitted to rasoul-e-akram hospital with acu...

conclusions when evaluating flank pain in patients, it is important to remember that cbc parameters may support urinary stone disease, and considering cbc results may be useful in the diagnosis of urinary stone disease. patients and methods this study was a retrospective observational study of 3,099 patients who were admitted to the urology outpatient clinic or diagnosed with urinary stone dise...

Hepatocyte retinoid X receptor alpha (RXRalpha)-deficient mice are more sensitive to ethanol toxicity than wild-type mice. Because RXRalpha-mediated pathways are implicated in lipid homeostasis and the inflammatory response, we hypothesized that a compromise in lipid metabolism and associated production of proinflammatory mediators are responsible for the hepatotoxicity observed in ethanol-trea...

The hypoxia-sensing transcriptional factor HIF1α is implicated in a variety of hepato-pathological conditions; however, the contribution of hepatocyte-derived HIF1α during progression of alcoholic liver injury is still controversial. HIF1α induces a variety of genes including those involved in apoptosis via p53 activation. Increased hepatocyte apoptosis is critical for progression of liver infl...

BACKGROUND AIMS Mesenchymal stromal cells (MSC) isolated from bone marrow (BM), adipose tissue and umbilical cord blood can be induced to differentiate into hepatocyte-like cells. MSC can also be isolated from umbilical cord Wharton's jelly (UC MSC), which can be easily obtained. UC MSC are more primitive MSC than those isolated from other tissue sources and do not express the major histocompat...