Both liver and kidney dysfunction are associated with adverse outcomes in critical illness. Advanced liver disease can be complicated by the hepatorenal syndrome (HRS) with liver transplantation offering the best long-term outcome. However, until recently, HRS was associated with such a poor prognosis that this group of patients rarely survived long enough for transplantation to be considered. ...

Hepatorenal syndrome (HRS) is a major complication in cirrhosis, with an annual incidence in patients with ascites of approximately 8%.1 It develops at the latest phase of the disease and, although initially considered without impact in prognosis (patients would die with and not by the renal failure), there is now evidence that it is an important determinant in survival. There are more reviews ...

Hepatorenal syndrome (HRS) is a functional renal failure that frequently develops in patients with advanced cirrhosis and severe impairment in systemic circulatory function. Traditionally it has been considered to be the consequence of a progression of the splanchnic arterial vasodilation occurring in these patients. However, recent data indicate that a reduction in cardiac output also plays a ...